Rh2(esp)2‐Catalyzed Coupling of α‐Diazo‐γ‐butyrolactams with Aromatic Amines,European Journal of Organic Chemistry

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Rh2(esp)2‐Catalyzed Coupling of α‐Diazo‐γ‐butyrolactams with Aromatic Amines
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2019-06-24 , DOI: 10.1002/ejoc.201900565
Daniil Zhukovsky ₁ , Dmitry Dar'in ₁ , Mikhail Krasavin ₁

Affiliation

α‐Arylamino‐γ‐butyrolactams are valuable scaffolds in medicinal chemistry. Their assembly has been achieved via NH‐insertion into an anilinic amino group of metal carbene species generated, via the use of Rh₂(esp)₂ catalyst, from the hitherto poorly explored α‐diazo‐γ‐butyrolactams. The reaction works well for aromatic and heteroaromatic (but not aliphatic) amines.

中文翻译：

Rh2（esp）2催化α-重氮-γ-丁内酰胺与芳香胺的偶联

α-芳基氨基-γ-丁内酰胺是药物化学中有价值的支架。它们的组装是通过将NH插入到迄今未充分探索的α-重氮-γ-丁内酰胺中，通过使用Rh ₂（esp）₂催化剂生成的金属卡宾物种的苯胺氨基来实现的。该反应对于芳族和杂芳族（但不是脂族）胺效果很好。

更新日期：2019-06-24

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