1·8 billion people of diverse ethnicities and cultures live in the Western Pacific Region. The increasing longevity of populations in this region is a major contributor to the exponential increase in Parkinson's disease prevalence worldwide. Differences exist between Parkinson's disease in the Western Pacific Region and in Europe and North America that might provide important insights into our understanding of the disease and approaches to management. For example, some genetic factors (such as LRRK2 mutations or variants) differ, environmental exposures might play differential roles in modulating the risk of Parkinson's disease, and fewer dyskinesias are reported, with some differences in the profile of non-motor symptoms and comorbidities. Gaps in awareness of the disease and inequitable access to treatments pose challenges. Further improvements in infrastructure, clinical governance, and services, and concerted collaborative efforts in training and research, including greater representation of the Western Pacific Region in clinical trials, will improve care of patients with Parkinson's disease in this region and beyond.

中文翻译：

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西太平洋区域的帕金森病

1·80 亿不同种族和文化的人生活在西太平洋区域。该地区人口寿命的延长是全球帕金森病患病率呈指数增长的主要原因。西太平洋地区的帕金森病与欧洲和北美的帕金森病之间存在差异，这可能为我们对该疾病的理解和管理方法提供重要的见解。例如，一些遗传因素（如 LRRK2 突变或变异）不同，环境暴露可能在调节帕金森病风险中发挥不同的作用，并且运动障碍的报道较少，非运动症状和合并症的特征存在一些差异。对疾病认识的差距和获得治疗的不公平性构成了挑战。