Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model.,Cell Host & Microbe

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Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model.
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2019-06-04 , DOI: 10.1016/j.chom.2019.05.001
Bryan B Hsu ₁ , Travis E Gibson ₂ , Vladimir Yeliseyev ₂ , Qing Liu ₂ , Lorena Lyon ₁ , Lynn Bry ₂ , Pamela A Silver ₁ , Georg K Gerber ₂

Affiliation

The human gut microbiome is comprised of densely colonizing microorganisms including bacteriophages, which are in dynamic interaction with each other and the mammalian host. To address how bacteriophages impact bacterial communities in the gut, we investigated the dynamic effects of phages on a model microbiome. Gnotobiotic mice were colonized with defined human gut commensal bacteria and subjected to predation by cognate lytic phages. We found that phage predation not only directly impacts susceptible bacteria but also leads to cascading effects on other bacterial species via interbacterial interactions. Metabolomic profiling revealed that shifts in the microbiome caused by phage predation have a direct consequence on the gut metabolome. Our work provides insight into the ecological importance of phages as modulators of bacterial colonization, and it additionally suggests the potential impact of gut phages on the mammalian host with implications for their therapeutic use to precisely modulate the microbiome.

中文翻译：

在小鼠模型中噬菌体对肠道菌群和代谢组的动态调节。

人的肠道微生物组由包括细菌噬菌体在内的紧密定居的微生物组成，它们彼此之间以及与哺乳动物宿主之间存在动态相互作用。为了解决噬菌体如何影响肠道细菌群落的问题，我们研究了噬菌体对模型微生物组的动态影响。生殖生物小鼠被定型的人类肠道共生细菌定殖，并通过同源裂解噬菌体进行捕食。我们发现噬菌体捕食不仅直接影响易感细菌，而且还通过细菌间相互作用导致对其他细菌物种的级联效应。代谢组学分析表明，由噬菌体捕食引起的微生物组变化对肠道代谢组有直接影响。我们的工作深入了解了噬菌体作为细菌定植调节剂的生态重要性，

更新日期：2019-06-04

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