The development of a phase-appropriate manufacturing-scale synthesis of potassium 2-fluoro-6-hydroxyphenyltrifluoroborate was achieved. Investigations into improving the yield and robustness indicated that pH of the reaction medium is a critical process parameter. Additional development resulted in replacing tartaric acid with citric acid, resulting in improved process robustness and enabling scale-up to >10 kg.

中文翻译：

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2-氟-6-羟基苯基三氟硼酸钾的工艺开发和生产

实现了对阶段合适的2-氟-6-羟基苯基三氟硼酸钾合成规模的合成方法的开发。对提高收率和耐用性的研究表明，反应介质的pH是关键的工艺参数。进一步的开发导致用柠檬酸代替酒石酸，从而提高了工艺的鲁棒性，并使规模扩大到了10公斤以上。