Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels.,Accounts of Chemical Research

当前位置： X-MOL 学术 › Acc. Chem. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels.
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2019-05-31 00:00:00 , DOI: 10.1021/acs.accounts.9b00075
Jacob K Hilton _{1,

2} , Minjoo Kim _{1,

2} , Wade D Van Horn _{1,

2}

Affiliation

The familiar pungent taste of spicy food, the refreshing taste of mint, and many other physiological phenomena are mediated by transient receptor potential (TRP) ion channels. TRP channels are a superfamily of ion channels that are sensitive to diverse chemical and physical stimuli and play diverse roles in biology. In addition to chemical regulation, some family members also sense common physical stimuli, such as temperature or pressure. Since their discovery and cloning in the 1990s and 2000s, understanding the molecular mechanisms governing TRP channel function and polymodal regulation has been a consistent but challenging goal. Until recently, a general lack of high-resolution TRP channel structures had significantly limited a molecular understanding of their function.

中文翻译：

结构和进化见解指向 TRP 离子通道的变构调节。

熟悉的辛辣食物的辛辣味、薄荷的清爽味道等许多生理现象都是由瞬时受体电位（TRP）离子通道介导的。TRP 通道是离子通道的超家族，对不同的化学和物理刺激敏感，在生物学中发挥着不同的作用。除了化学调节外，一些家庭成员还会感知常见的物理刺激，例如温度或压力。自从他们在 1990 年代和 2000 年代被发现和克隆以来，了解控制 TRP 通道功能和多模态调节的分子机制一直是一个一致但具有挑战性的目标。直到最近，普遍缺乏高分辨率的 TRP 通道结构已经大大限制了对其功能的分子理解。

更新日期：2019-05-31

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南