Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery,ACS Nano

当前位置： X-MOL 学术 › ACS Nano › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery
ACS Nano ( IF 15.8 ) Pub Date : 2018-02-19 00:00:00 , DOI: 10.1021/acsnano.7b08152
Jinqiang Wang _{1,

2} , Yanqi Ye _{1,

2} , Jicheng Yu _{1,

2} , Anna R. Kahkoska ₃ , Xudong Zhang _{1,

2} , Chao Wang _{1,

2} , Wujin Sun _{1,

2} , Ria D. Corder ₄ , Zhaowei Chen _{1,

2} , Saad A. Khan ₄ , John B. Buse ₃ , Zhen Gu _{1,

2,

3}

Affiliation

A bioinspired glucose-responsive insulin delivery system for self-regulation of blood glucose levels is desirable for improving health and quality of life outcomes for patients with type 1 and advanced type 2 diabetes. Here we describe a painless core–shell microneedle array patch consisting of degradable cross-linked gel for smart insulin delivery with rapid responsiveness and excellent biocompatibility. This gel-based device can partially dissociate and subsequently release insulin when triggered by hydrogen peroxide (H₂O₂) generated during the oxidation of glucose by a glucose-specific enzyme covalently attached inside the gel. Importantly, the H₂O₂-responsive microneedles are coated with a thin-layer embedding H₂O₂-scavenging enzyme, thus mimicking the complementary function of enzymes in peroxisomes to protect normal tissues from injury caused by oxidative stress. Utilizing a chemically induced type 1 diabetic mouse model, we demonstrated that this smart insulin patch with a bioresponsive core and protective shell could effectively regulate the blood glucose levels within a normal range with improved biocompatibility.

中文翻译：

核壳微针凝胶，可自我调节胰岛素的输送

为了改善1型和2型糖尿病患者的健康状况和生活质量，需要一种可自我调节血糖水平的生物启发性葡萄糖反应性胰岛素输送系统。在这里，我们描述了一种无痛的核-壳微针阵列贴片，该贴片由可降解的交联凝胶组成，可实现智能胰岛素的快速响应和出色的生物相容性。当由过氧化氢（H ₂ O ₂）触发时，该基于凝胶的装置可以部分解离并随后释放胰岛素，所述过氧化氢是通过共价附着在凝胶内的葡萄糖特异性酶在葡萄糖氧化过程中产生的。重要的是，对H ₂ O ₂敏感的微针涂有一层薄薄的嵌入H ₂O _2-清除酶，从而模仿过氧化物酶体中酶的互补功能，以保护正常组织免受氧化应激造成的伤害。利用化学诱导的1型糖尿病小鼠模型，我们证明了这种具有生物反应性核心和保护壳的智能胰岛素贴剂可以在正常范围内有效调节血糖水平，并改善生物相容性。

更新日期：2018-02-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南