Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines.,Trends in Immunology

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Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines.
Trends in Immunology ( IF 13.1 ) Pub Date : 2019-05-30 , DOI: 10.1016/j.it.2019.05.003
Marco Antonio Cassatella ₁ , Nataliya K Östberg ₂ , Nicola Tamassia ₁ , Oliver Soehnlein ₃

Affiliation

Neutrophils, the most abundant white blood cells in human circulation, entertain intense interactions with other leukocyte subsets, platelets, and stromal cells. Molecularly, such interactions are typically communicated through proteins generated during granulopoiesis, stored in granules, or produced on demand. Here, we provide an overview of the mammalian regulation of granule protein production in the bone marrow and the de novo synthesis of cytokines by neutrophils recruited to tissues. In addition, we discuss some of the known biological roles of these protein messengers, and how neutrophil-borne granule proteins and cytokines can synergize to modulate inflammation and tumor development. Decoding the neutrophil interactome is important for therapeutically neutralizing individual proteins to putatively dampen inflammation, or for delivering modified neutrophil-borne proteins to boost host defense.

中文翻译：

中性粒细胞衍生的颗粒蛋白和细胞因子的生物学作用。

中性粒细胞是人类循环中最丰富的白细胞，可与其他白细胞亚群，血小板和基质细胞发生强烈的相互作用。在分子上，这种相互作用通常通过粒细胞生成过程中产生，存储在颗粒中或按需产生的蛋白质进行交流。在这里，我们概述了哺乳动物中骨髓中颗粒蛋白生产的调节以及由募集到组织的中性粒细胞从头合成细胞因子的过程。此外，我们讨论了这些蛋白信使的某些已知生物学作用，以及中性粒细胞携带的颗粒蛋白和细胞因子如何协同调节炎症和肿瘤的发展。解码嗜中性粒细胞相互作用组对于治疗性中和单个蛋白质以假定地减轻炎症非常重要，

更新日期：2019-05-31

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