Recent Advances and Challenges in Luminescent Imaging: Bright Outlook for Chemiluminescence of Dioxetanes in Water.,ACS Central Science

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Recent Advances and Challenges in Luminescent Imaging: Bright Outlook for Chemiluminescence of Dioxetanes in Water.
ACS Central Science ( IF 12.7 ) Pub Date : 2019-05-29 , DOI: 10.1021/acscentsci.9b00372
Nir Hananya ₁ , Doron Shabat ₁

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Chemiluminescence is gradually being recognized as a powerful tool for sensing and imaging. Most known light-emitting compounds undergo chemiexcitation through spontaneous decomposition of cyclic peroxide moieties. A ground-breaking milestone in the chemistry of such compounds was achieved 30 years ago with the discovery of triggerable dioxetanes by Schaap's group. Our group has recently developed a distinct methodology to significantly improve the light emission efficiency of such phenoxy-dioxetane luminophores under physiological conditions. Introduction of an electron-withdrawing substituent at the ortho position of the phenoxy-dioxetane resulted in an approximately 3000-fold increase of the chemiluminescence quantum yield in aqueous media. Furthermore, we discovered that the emission wavelength and the kinetics of the chemiexcitation could be determined by the electronic nature of the substituent incorporated on the dioxetane luminophore. This recent development has provided scientists with new powerful chemiluminophores that can act as single-component probes for in vivo and in vitro detection and imaging of various analytes and enzymes. This outlook describes the recent progress toward applications of synthetic chemiluminescence luminophores suitable for sensing and imaging in aqueous environments.

中文翻译：

发光成像的最新进展和挑战：水中二恶丁环化学发光的光明前景。

化学发光逐渐被认为是用于传感和成像的强大工具。大多数已知的发光化合物通过环状过氧化物部分的自发分解而经历化学激发。早在30年前，Schaap研究小组发现了可触发的二氧环乙烷，就在此类化合物的化学研究中取得了突破性的里程碑。我们的小组最近开发了一种独特的方法，可以在生理条件下显着提高此类苯氧基-二氧杂环丁烷发光体的发光效率。在苯氧基-二氧杂环丁烷的邻位引入吸电子取代基导致在水性介质中化学发光量子产率提高约3000倍。此外，我们发现，化学激发的发射波长和动力学可以由结合在二氧杂环丁烷发光体上的取代基的电子性质决定。这一最新进展为科学家提供了新型强大的化学发光体，它们可作为单组分探针用于体内和体外检测和成像各种分析物和酶。该观点描述了适用于水性环境中的传感和成像的合成化学发光发光体的最新应用进展。这一最新进展为科学家提供了新型强大的化学发光体，它们可作为单组分探针用于体内和体外检测和成像各种分析物和酶。该观点描述了适用于水性环境中的传感和成像的合成化学发光发光体的最新应用进展。这一最新进展为科学家提供了新型强大的化学发光体，它们可作为单组分探针用于体内和体外检测和成像各种分析物和酶。该观点描述了适用于水性环境中的传感和成像的合成化学发光发光体的最新应用进展。

更新日期：2019-05-29

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