Recent advances in the design of injectable hydrogels for stem cell-based therapy,Journal of Materials Chemistry B

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Recent advances in the design of injectable hydrogels for stem cell-based therapy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-05-29 00:00:00 , DOI: 10.1039/c9tb00485h
Kun Liang _{1,

2,

3} , Ki Hyun Bae _{1,

2,

3} , Motoichi Kurisawa _{1,

2,

3}

Affiliation

Stem cell therapy holds promise for the treatment of many diseases but the efficacy is limited by the unfavorable environments in the impaired tissues. The use of hydrogel scaffolds has been proposed as a strategy to overcome this by improving the survival and engraftment of injected stem cells. In particular, injectable hydrogels are deemed highly attractive owing to their ease of use, shape adaptability and ability to access parts of the body that are difficult to reach. In this review, we provide an overview of the recent efforts in the design of various injectable hydrogels for stem cell-based tissue engineering. Herein, we first discuss the different aspects of hydrogels’ physical properties that can regulate stem cell behavior. In addition, we examine in detail the biomaterial (natural, synthetic or hybrid) composition and characteristics of hydrogel matrices used in regenerative medical applications involving stem cells. Lastly, we outline some representative next-generation hydrogel systems with additional features to potentially enhance the therapeutic efficacy and finally we provide a summary and outlook on developments in the field.

中文翻译：

基于干细胞疗法的可注射水凝胶设计的最新进展

干细胞疗法有望治疗许多疾病，但其功效受到受损组织中不利环境的限制。已经提出使用水凝胶支架作为通过改善注射的干细胞的存活和移植来克服该问题的策略。特别地，由于可注射水凝胶的易用性，形状适应性和进入难以到达的身体部位的能力，因此被认为具有高度吸引力。在这篇综述中，我们提供了基于干细胞的组织工程设计各种可注射水凝胶的最新研究成果的概述。在这里，我们首先讨论可以调节干细胞行为的水凝胶物理特性的不同方面。此外，我们还将详细研究生物材料（天然，合成或杂合）的水凝胶基质的组成和特性，涉及涉及干细胞的再生医学应用。最后，我们概述了一些具有代表性的下一代水凝胶系统，这些系统具有可能增强治疗功效的其他功能，最后，我们对本领域的发展进行了总结和展望。

更新日期：2019-05-29

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