The first synthesis of racemic 2-(aminomethyl)cyclopropane-1,1-dicarboxylic acid was developed involving sequential iodocarbocyclization, azidation, saponification and reduction of dimethyl 2-allylmalonate. The developed synthetic pathway avoids reactions such as ring opening of the cyclopropane ring toward acyclic delta-amino carboxylic acid derivatives or lactamisation toward bicyclic methyl 3-aza-2-oxobicyclo[3.1.0]hexane-1-carboxylates which occur in alternative synthetic strategies.

中文翻译：

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外消旋 2-(氨基甲基) 环丙烷-1,1-二羧酸作为一种新的约束 γ-氨基二羧酸绕过 3-氮杂-2-氧代双环 [3.1.0] 己烷-1-羧酸烷基酯的合成

外消旋 2-(氨基甲基) 环丙烷-1,1-二羧酸的首次合成涉及顺序碘碳环化、叠氮化、皂化和 2-烯丙丙二酸二甲酯的还原。开发的合成途径避免了诸如环丙烷环向无环 δ-氨基羧酸衍生物开环或向双环甲基 3-氮杂-2-氧代双环 [3.1.0] 己烷-1-羧酸酯的内酰胺化等反应，这些反应发生在替代合成策略中.