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A Mn(III)-Sealed Metal–Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics
ACS Nano ( IF 15.8 ) Pub Date : 2019-05-28 00:00:00 , DOI: 10.1021/acsnano.9b00300 Shuang-Shuang Wan 1 , Qian Cheng 1 , Xuan Zeng 1 , Xian-Zheng Zhang 1
ACS Nano ( IF 15.8 ) Pub Date : 2019-05-28 00:00:00 , DOI: 10.1021/acsnano.9b00300 Shuang-Shuang Wan 1 , Qian Cheng 1 , Xuan Zeng 1 , Xian-Zheng Zhang 1
Affiliation
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Here, a Mn(III)-sealed metal–organic framework (MOF) nanosystem based on coordination between Mn(III) and porphyrin (TCPP) via a one-pot method was designed and constructed. Mn(III), as a sealer, not only quenched TCPP-based fluorescence but also inhibited reactive oxygen species (ROS) generation, which made MOFs an “inert” theranostic nanoparticle. Interestingly, upon endocytosis by tumor cells, MOFs were disintegrated into Mn(II) and free TCPP by intracellular glutathione (GSH) in tumor cells, owing to redox reaction between Mn(III) and GSH. This disintegration would lead to consumption of antioxidant GSH and activated Mn(II)-based magnetic resonance imaging (MRI) as well as TCPP-based fluorescent imaging. More importantly, such a GSH-regulated TCPP release could implement controllable ROS generation under irradiation, which avoided side effects (inflammation and damage of normal tissues). As a consequence, after unlocking by GSH, Mn(III)-sealed MOFs could significantly improve the therapeutic efficiency of photodynamic therapy by combining controlled ROS generation and GSH depletion after precise dual tumor homing.
中文翻译：
锰（III）密封的金属有机骨架纳米系统用于氧化还原解锁的肿瘤治疗学。
这里，锰（III）的基础上协调的Mn（III）和卟啉（TCPP）之间-sealed金属-有机构架（MOF）纳米系统经由设计并构建了一种一锅法。Mn（III）作为封闭剂，不仅可以淬灭基于TCPP的荧光，而且可以抑制活性氧（ROS）的生成，这使MOF成为“惰性”的治疗性纳米颗粒。有趣的是，在肿瘤细胞内吞后，由于Mn（III）与GSH之间的氧化还原反应，MOF被肿瘤细胞内的细胞内谷胱甘肽（GSH）分解成Mn（II）和游离TCPP。这种崩解将导致抗氧化剂GSH和活化的基于Mn（II）的磁共振成像（MRI）以及基于TCPP的荧光成像的消耗。更重要的是，这种GSH调节的TCPP释放可以在辐射下实现可控的ROS生成，从而避免了副作用（炎症和正常组织的损伤）。因此，在GSH解锁后，
更新日期：2019-05-28
中文翻译：
锰（III）密封的金属有机骨架纳米系统用于氧化还原解锁的肿瘤治疗学。
这里，锰（III）的基础上协调的Mn（III）和卟啉（TCPP）之间-sealed金属-有机构架（MOF）纳米系统经由设计并构建了一种一锅法。Mn（III）作为封闭剂，不仅可以淬灭基于TCPP的荧光，而且可以抑制活性氧（ROS）的生成，这使MOF成为“惰性”的治疗性纳米颗粒。有趣的是，在肿瘤细胞内吞后，由于Mn（III）与GSH之间的氧化还原反应，MOF被肿瘤细胞内的细胞内谷胱甘肽（GSH）分解成Mn（II）和游离TCPP。这种崩解将导致抗氧化剂GSH和活化的基于Mn（II）的磁共振成像（MRI）以及基于TCPP的荧光成像的消耗。更重要的是，这种GSH调节的TCPP释放可以在辐射下实现可控的ROS生成，从而避免了副作用（炎症和正常组织的损伤）。因此，在GSH解锁后，
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