小分子基于卟啉的有机纳米粒子具有显着的光热转化效率，可用于体内光声成像和光热疗法。,ACS Applied Materials & Interfaces

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小分子基于卟啉的有机纳米粒子具有显着的光热转化效率，可用于体内光声成像和光热疗法。
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2019-06-04 , DOI: 10.1021/acsami.9b06866
Fengshou Wu ₁ , Li Chen ₁ , Liangliang Yue ₁ , Kai Wang ₂ , Kai Cheng ₃ , Jun Chen ₄ , Xiaogang Luo ₁ , Tao Zhang ₅

Affiliation

考虑到安全性和配方方面的问题，吸收近红外（NIR）的有机纳米颗粒（ONP）成为了“一对一”治疗用纳米材料的新兴候选材料。然而，在临床上可行的候选物出现之前，可能需要简便的制造方法以及光热转化效率（PCE）和光稳定性的改进。在此，合成了具有供体-受体结构的新型有机化合物[卟啉-二酮吡咯并吡咯（Por-DPP）]，其中卟啉用作供体单元，而二酮吡咯并吡咯用作受体单元。Por-DPP表现出从可见光到NIR区域的有效吸收。自组装成纳米颗粒（NPs）（〜120 nm）后，Por-DPP NPs的吸收光谱变宽并发生红移，相对于有机分子。此外，NP的结构增强了受体-施主结构，导致发射猝灭并促进了非辐射热的产生。经测量，Por-DPP NP的PCE为62.5％，高于大多数ONP。在808 nm激光照射下，Por-DPP NP在体外具有独特的光热疗法（PTT）效果，并且可以在光疗法后在体内有效地破坏癌细胞而没有明显的副作用。因此，具有高PCE的基于小分子卟啉的ONPs在光声成像引导的PTT中显示出有希望的应用。高于大多数ONP。在808 nm激光照射下，Por-DPP NP在体外具有独特的光热疗法（PTT）效果，并且可以在光疗法后在体内有效地破坏癌细胞而没有明显的副作用。因此，具有高PCE的基于小分子卟啉的ONPs在光声成像引导的PTT中显示出有希望的应用。高于大多数ONP。在808 nm激光照射下，Por-DPP NP在体外具有独特的光热疗法（PTT）效果，并且可以在光疗法后在体内有效地破坏癌细胞而没有明显的副作用。因此，具有高PCE的基于小分子卟啉的ONPs在光声成像引导的PTT中显示出有希望的应用。

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Small-Molecule Porphyrin-Based Organic Nanoparticles with Remarkable Photothermal Conversion Efficiency for in Vivo Photoacoustic Imaging and Photothermal Therapy.

Near-infrared (NIR)-absorbing organic nanoparticles (ONPs) are emerging candidates for "one-for-all" theranostic nanomaterials with considerations of safety and formulation in mind. However, facile fabrication methods and improvements in the photothermal conversion efficiency (PCE) and photostability are likely needed before a clinically viable set of candidates emerges. Herein, a new organic compound, [porphyrin-diketopyrrolopyrrole (Por-DPP)] with the donor-acceptor structure was synthesized, where porphyrin was used as a donor unit while diketopyrrolopyrrole was used as an acceptor unit. Por-DPP exhibited efficient absorption extending from visible to NIR regions. After self-assembling into nanoparticles (NPs) (∼120 nm), the absorption spectrum of Por-DPP NPs broadened and red-shifted to some extent, relative to that of organic molecules. Furthermore, the architecture of NPs enhanced the acceptor-donor structure, leading to emission quenching and facilitating nonradiative thermal generation. The PCE of Por-DPP NPs was measured and calculated to be 62.5%, higher than most of ONPs. Under 808 nm laser irradiation, the Por-DPP NPs possessed a distinct photothermal therapy (PTT) effect in vitro and can damage cancer cells efficiently in vivo without significant side effects after phototherapy. Thus, the small-molecule porphyrin-based ONPs with high PCE demonstrated promising application in photoacoustic imaging-guided PTT.

更新日期：2019-05-23

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