Multifunctional DNA Origami Nanoplatforms for Drug Delivery,Chemistry - An Asian Journal

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Multifunctional DNA Origami Nanoplatforms for Drug Delivery
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2019-06-17 , DOI: 10.1002/asia.201900574
Xuehe Lu _{1,

2} , Jianbing Liu ₂ , Xiaohui Wu _{2,

3} , Baoquan Ding _{1,

2,

3}

Affiliation

DNA nanotechnology has been employed in the construction of self‐assembled nano‐biomaterials with uniform size and shape for various biological applications, such as bioimaging, diagnosis, or therapeutics. Herein, recent successful efforts to utilize multifunctional DNA origami nanoplatforms as drug‐delivery vehicles are reviewed. Diagnostic and therapeutic strategies based on gold nanorods, chemotherapeutic drugs, cytosine–phosphate–guanine, functional proteins, gene drugs, and their combinations for optoacoustic imaging, photothermal therapy, chemotherapy, immunological therapy, gene therapy, and coagulation‐based therapy are summarized. The challenges and opportunities for DNA‐based nanocarriers for biological applications are also discussed.

中文翻译：

用于药物递送的多功能DNA折纸纳米平台

DNA纳米技术已被用于构建大小和形状均一的自组装纳米生物材料，用于各种生物应用，例如生物成像，诊断或治疗。在此，回顾了最近成功利用多功能DNA折纸纳米平台作为药物递送载体的成功努力。总结了基于金纳米棒，化学治疗药物，胞嘧啶-磷酸-鸟嘌呤，功能蛋白，基因药物及其组合的光声成像，光热疗法，化学疗法，免疫疗法，基因疗法和基于凝血的疗法的诊断和治疗策略。还讨论了用于生物应用的基于DNA的纳米载体的挑战和机遇。

更新日期：2019-06-17

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