Surface Modification by Divalent Main-Group-Elemental Ions for Improved Bone Remodeling To Instruct Implant Biofabrication,ACS Biomaterials Science & Engineering

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Surface Modification by Divalent Main-Group-Elemental Ions for Improved Bone Remodeling To Instruct Implant Biofabrication
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2019-05-23 00:00:00 , DOI: 10.1021/acsbiomaterials.9b00270
Jiaxing Gong _{1,

2,

3} , Miao Sun _{1,

3} , Shaolong Wang _{1,

3} , Jianxiang He _{1,

3} , Yu Wang _{1,

3} , Ying Qian _{1,

3} , Yu Liu _{1,

3} , Lingqing Dong _{1,

3,

4} , Liang Ma ₅ , Kui Cheng ₄ , Wenjian Weng ₄ , Mengfei Yu _{1,

3} , Yu Shrike Zhang ₂ , Huiming Wang _{1,

3}

Affiliation

Divalent main-group-elemental ions are widely used to improve osteogenic capacity of implants biofabricated from Ti and its alloys. However, the conclusions regarding their osseointegration and immunogenicity are always inconsistent because of the multiple bone remodeling processes as well as the distinct material surface features arising from processing. Here we successfully manufactured the porous micro/nanostructured surface topography with divalent main-group-elemental ions (Mg²⁺, Ca²⁺, Sr²⁺, Ba²⁺) on substrates through hydrothermal treatment and comprehensively evaluated the complex bone remodeling processes, including osseointegration, immunogenicity, and fibrosis of substrates and implants. We found that Sr-modified implants not only upregulated the adhesion and proliferation of mesenchymal stem cells but also the differentiation of osteogenic markers compared with those modified by other divalent main-group-elemental ions (Mg²⁺, Ca²⁺, Ba²⁺). More importantly, the osteoclastogenesis, immunogenicity, and fibrosis of Sr-modified implants were also significantly downregulated. In vivo, evaluations of new bone formation and histological morphology at the interface of implant and host as well as the removal torque similarly indicated the improved osseointegration of Sr-modified implants as well as the absence of immunogenicity, fibrosis, or necrosis. Our results suggested that among various divalent main-group-elemental ions, Sr²⁺ might be a promising one for enhancing bone remodeling, which can be used to instruct functionalization of the surfaces of biofabricated Ti-based orthopedic and dental implants in the future.

中文翻译：

通过二价主族元素离子进行表面修饰，以改善骨骼重塑，从而指导植入物的生物制造

二价主族元素离子被广泛用于提高由Ti及其合金生物制成的植入物的成骨能力。然而，由于多种骨重塑过程以及加工过程中产生的独特物质表面特征，有关它们的骨整合和免疫原性的结论始终是不一致的。在这里，我们成功地制造了具有二价主族元素离子（Mg 2 ⁺，Ca 2 ⁺，Sr 2 ⁺，Ba ²⁺）进行水热处理，并全面评估了复杂的骨骼重塑过程，包括骨整合，免疫原性以及基质和植入物的纤维化。我们发现，与其他二价主族元素离子（Mg 2 ⁺，Ca 2 ⁺，Ba ²⁺）。更重要的是，Sr修饰植入物的破骨细胞生成，免疫原性和纤维化也显着下调。体内，评估植入物和宿主界面处的新骨形成和组织形态以及去除扭矩同样表明，Sr修饰植入物的骨整合改善，并且没有免疫原性，纤维化或坏死。我们的研究结果表明，在各种二价主族元素离子中，Sr ²⁺可能是一种有希望的增强骨重塑的离子，可用于指导未来人造Ti基骨科和牙科植入物的表面功能化。

更新日期：2019-05-23

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