Development of a 3D-Printed Drug-Eluting Stent for Treating Obstructive Salivary Gland Disease,ACS Biomaterials Science & Engineering

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Development of a 3D-Printed Drug-Eluting Stent for Treating Obstructive Salivary Gland Disease
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2019-05-23 00:00:00 , DOI: 10.1021/acsbiomaterials.9b00636
Tae Ho Kim , Ji-Hyun Lee , Chi Bum Ahn , Jeong Hee Hong , Kuk Hui Son ₁ , Jin Woo Lee

Affiliation

Most studies of obstructive salivary gland disease have reported only statistical aspects, surgical operations, and prescriptions and have simulated the phenomena occurring in the salivary glands and ductal tissues. However, no direct lesion treatments involving drug-eluting stents have been used to reduce salivary pooling induced by inflammation. In this study, a biodegradable polymer polycaprolactone (PCL)-based antibiotic-eluting stent was developed to treat recurrent obstructive salivary gland disease. The structure’s diameter was designed after consideration of the human anatomical structure, and the data were processed in a form suitable for three-dimensional (3D) printing via computer-aided design and manufacturing. After the proper mixing conditions of the antibiotics and PCL were ensured, the optimized printing conditions were secured and the stent was successfully printed with the original lumen size diameter maintained. Amoxicillin and cefotaxime, the antibiotics loaded in this study, did not lose their original antimicrobial activity under the 3D printing process and were effectively released from the constructs for verification of the antimicrobial activity against the causative bacteria according to their concentrations. In addition, antibiotic-eluting stents fabricated in a mesh-like network form were proven stable and capable of sustained release, thereby demonstrating the possibility of treating recurrent obstruction salivary gland disease.

中文翻译：

3D打印药物洗脱支架治疗阻塞性唾液腺疾病的开发

大多数阻塞性唾液腺疾病的研究仅报道了统计方面，外科手术和处方，并模拟了唾液腺和导管组织中发生的现象。但是，尚未使用涉及药物洗脱支架的直接病变治疗来减少炎症引起的唾液汇集。在这项研究中，开发了一种基于生物可降解聚合物聚己内酯（PCL）的抗生素洗脱支架，以治疗复发性阻塞性涎腺疾病。在考虑人体解剖结构后设计结构的直径，并通过计算机辅助设计和制造以适合于三维（3D）打印的形式处理数据。在确保抗生素和PCL适当混合后，确保最佳的打印条件，并在保持原始管腔尺寸直径的情况下成功地打印出支架。本研究中加载的抗生素阿莫西林和头孢噻肟在3D打印过程中没有失去其原有的抗菌活性，并根据其浓度从构建物中有效释放出来，以验证对致病细菌的抗菌活性。另外，以网状网络形式制造的抗生素洗脱支架被证明是稳定的并且能够持续释放，从而证明了治疗复发性阻塞性唾液腺疾病的可能性。不会在3D打印过程中失去其原始的抗菌活性，并且会根据其浓度从构建体中有效释放出来，以验证其对致病细菌的抗菌活性。另外，以网状网络形式制造的抗生素洗脱支架被证明是稳定的并且能够持续释放，从而证明了治疗复发性阻塞性唾液腺疾病的可能性。不会在3D打印过程中失去其原始的抗菌活性，并且会根据其浓度从构建体中有效释放出来，以验证其对致病细菌的抗菌活性。另外，以网状网络形式制造的抗生素洗脱支架被证明是稳定的并且能够持续释放，从而证明了治疗复发性阻塞性唾液腺疾病的可能性。

更新日期：2019-05-23

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