All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy,Advanced Functional Materials

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All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-05-23 , DOI: 10.1002/adfm.201901480
Qi Wang _{1,

2} , Yeneng Dai ₁ , Jingzeng Xu ₁ , Jie Cai ₁ , Xinrui Niu ₁ , Lei Zhang ₁ , Runfeng Chen ₁ , Qingming Shen ₁ , Wei Huang ₁ , Quli Fan ₁

Affiliation

Development of single near‐infrared (NIR) laser triggered phototheranostics for multimodal imaging guided combination therapy is highly desirable but is still a big challenge. Herein, a novel small‐molecule dye DPP‐BT is designed and synthesized, which shows strong absorption in the first NIR window (NIR‐I) and fluorescence emission in the second NIR region (NIR‐II). Such a dye not only acts as a dual‐modal contrast agent for NIR‐II fluorescence and photoacoustic (PA) imaging, but also serves as a combined therapeutic agent for photothermal therapy (PTT) and photodynamic therapy (PDT). The single NIR laser triggered all‐in‐one phototheranostic nanoparticles are constructed by encapsulating the dye DPP‐BT, chemotherapy drug DOX, and natural phase‐change materials with a folic acid functionalized amphiphile. Notably, under NIR laser irradiation, DOX can effectively release from such nanoparticles via NIR‐induced hyperthermia of DPP‐BT. By intravenous injection of such nanoparticles into Hela tumor‐bearing mice, the tumor size and location can be accurately observed via NIR‐II fluorescence/PA dual‐modal imaging. From in vitro and in vivo therapy results, such nanoparticles simultaneously present remarkable antitumor efficacy by PTT/PDT/chemo combination therapy, which is triggered by a single NIR laser. Overall, this work provides an innovative strategy to design and construct all‐in‐one nanoplatforms for clinical phototheranostics.

中文翻译：

多合一光热学：单激光触发NIR-II荧光/光声成像引导光热/光动力/化学联合疗法

迫切需要开发一种用于多峰成像引导联合治疗的近红外（NIR）激光触发光热学技术，但这仍然是一个巨大的挑战。本文设计并合成了一种新型的小分子染料DPP-BT，它在第一个NIR窗口（NIR-I）中显示出强大的吸收能力，在第二个NIR区域（NIR-II）中显示出荧光发射。这种染料不仅充当NIR-II荧光和光声（PA）成像的双峰造影剂，而且还充当光热疗法（PTT）和光动力疗法（PDT）的组合治疗剂。通过将染料DPP-BT，化疗药物DOX和天然相变材料与叶酸官能化的两亲物包封在一起，构造了单个NIR激光触发的多合一光热敏纳米颗粒。尤其是在NIR激光照射下 DOX可以通过NIR诱导的DPP-BT热疗从此类纳米颗粒中有效释放。通过将此类纳米颗粒静脉注射到带有Hela荷瘤的小鼠中，可以通过NIR-II荧光/ PA双模态成像准确观察到肿瘤的大小和位置。从体外和体内治疗结果来看，此类纳米颗粒通过PTT / PDT /化学联合疗法同时显示出显着的抗肿瘤功效，这是由单个NIR激光触发的。总的来说，这项工作为设计和构建用于临床光热学的多功能纳米平台提供了一种创新策略。通过NIR-II荧光/ PA双模态成像可以准确观察到肿瘤的大小和位置。从体外和体内治疗结果来看，此类纳米颗粒通过PTT / PDT /化学联合疗法同时显示出显着的抗肿瘤功效，这是由单个NIR激光触发的。总体而言，这项工作为设计和构建用于临床光热学的多功能纳米平台提供了一种创新策略。通过NIR-II荧光/ PA双模态成像可以准确观察到肿瘤的大小和位置。从体外和体内治疗结果来看，此类纳米颗粒通过PTT / PDT /化学联合疗法同时显示出显着的抗肿瘤功效，这是由单个NIR激光触发的。总体而言，这项工作为设计和构建用于临床光热学的多功能纳米平台提供了一种创新策略。

更新日期：2019-05-23

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