Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins,Angewandte Chemie International Edition

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Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2019-05-22 , DOI: 10.1002/anie.201906154
Feng Liu _{1,

2,

3} , Hua Wang ₂ , Suhua Li _{2,

4} , Grant A. L. Bare ₂ , Xuemin Chen ₅ , Chu Wang ₅ , John E. Moses ₆ , Peng Wu ₇ , K. Barry Sharpless ₂

Affiliation

New biocompatible SOF₄‐based SuFEx reactions operating at low concentration in aqueous solution under mild pH and temperature conditions provide access to asymmetric and trisubstituted products at the sulfur(VI) center with versatile S−N and S−O connectivity. The SuFEx bioconjugation of iminosulfur oxydifluorides to either BSA protein or to single‐stranded DNA is demonstrated. Details can be found in the Communication (10.1002/anie.201902489) by K. B. Sharpless et al.

中文翻译：

具有生物相容性的SuFEx Click化学方法：亚硫酰四氟化物（SOF ₄）-衍生的连接集线器，可与DNA和蛋白质进行生物偶联

新的基于生物相容性SOF ₄的SuFEx反应可在温和的pH和温度条件下以低浓度在水溶液中运行，提供了具有通用的S-N和S-O连接性的，在硫（VI）中心获得不对称和三取代产物的途径。证明了二氟化亚氨基硫磺与BSA蛋白或单链DNA的SuFEx生物共轭。可以在K.B.Sharpless等人的来文（10.1002 / anie.201902489）中找到详细信息。

更新日期：2019-05-22

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