PI3K isoforms in cell signalling and vesicle trafficking.,Nature Reviews Molecular Cell Biology

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PI3K isoforms in cell signalling and vesicle trafficking.
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2019-09-01 , DOI: 10.1038/s41580-019-0129-z
Benoit Bilanges ₁ , York Posor ₁ , Bart Vanhaesebroeck ₁

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PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided into three classes. The class I PI3Ks generate 3-phosphoinositide lipids, which directly activate signal transduction pathways. In addition to being frequently genetically activated in cancer, similar mutations in class I PI3Ks have now also been found in a human non-malignant overgrowth syndrome and a primary immune disorder that predisposes to lymphoma. The class II and class III PI3Ks are regulators of membrane traffic along the endocytic route, in endosomal recycling and autophagy, with an often indirect effect on cell signalling. Here, we summarize current knowledge of the different PI3K classes and isoforms, focusing on recently uncovered biological functions and the mechanisms by which these kinases are activated. Deeper insight into the PI3K isoforms will undoubtedly continue to contribute to a better understanding of fundamental cell biological processes and, ultimately, of human disease.

中文翻译：

细胞信号传导和囊泡运输中的 PI3K 亚型。

PI3K 是脂质激酶家族，可磷酸化细胞内肌醇脂质以调节信号传导和细胞内囊泡运输。哺乳动物有八种 PI3K 亚型，分为三类。 I 类 PI3K 产生 3-磷酸肌醇脂质，直接激活信号转导途径。除了在癌症中经常被基因激活外，现在还在人类非恶性过度生长综合征和易患淋巴瘤的原发性免疫疾病中发现了类似的 I 类 PI3K 突变。 II 类和 III 类 PI3K 是内吞途径、内体循环和自噬中膜运输的调节剂，通常对细胞信号传导产生间接影响。在这里，我们总结了当前对不同 PI3K 类别和亚型的了解，重点关注最近发现的生物学功能以及这些激酶被激活的机制。对 PI3K 同工型的更深入了解无疑将继续有助于更好地理解基本细胞生物学过程，并最终有助于更好地理解人类疾病。

更新日期：2019-05-21

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