Virus‐Like Particle Engineering: From Rational Design to Versatile Applications,Biotechnology Journal

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Virus‐Like Particle Engineering: From Rational Design to Versatile Applications
Biotechnology Journal ( IF 3.2 ) Pub Date : 2018-03-05 , DOI: 10.1002/biot.201700324
Xuanwei Ding _{1,

2} , Dong Liu ₁ , George Booth ₃ , Wei Gao _{1,

2} , Yuan Lu ₁

Affiliation

As mimicking natural virus structures, virus‐like particles (VLPs) have evolved to become a widely accepted technology used for humans which are safe, highly efficacious, and profitable. Several remarkable advantages have been achieved to revolutionize the molecule delivery for diverse applications in nanotechnology, biotechnology, and medicine. Here, the rational structure design, manufacturing process, functionalization strategy, and emerging applications of VLPs is reviewed. The situation and challenges in the VLP engineering, the key development orientation, and future applications have been discussed. To develop a good VLP design concept, the virus/VLP‐host interactions need to be examined and the screening methods of the VLP stabilization factors need to be established. The functionalization toolbox can be expanded to fabricate smart, robust, and multifunctional VLPs. Novel robust VLP manufacturing platforms are required to deliver vaccines in resource‐poor regions with a significant reduction in the production time and cost. The future applications of VLPs are always driven by the development of emerging technologies and new requirements of modern life.

中文翻译：

像病毒一样的粒子工程：从合理设计到通用应用程序

随着模仿天然病毒结构的发展，病毒样颗粒（VLP）已经发展成为一种安全，高效且可获利的人类广泛使用的技术。为了在纳米技术，生物技术和医学中的各种应用中革新分子的输送方式，已经取得了几项显着的优势。在此，对VLP的合理结构设计，制造过程，功能化策略和新兴应用进行了回顾。讨论了VLP工程中的情况和挑战，关键的开发方向以及未来的应用。为了发展良好的VLP设计概念，需要检查病毒/ VLP-宿主之间的相互作用，并建立VLP稳定因子的筛选方法。可以扩展功能工具箱，以制造智能，强大，和多功能VLP。需要新型强大的VLP制造平台来在资源匮乏的地区交付疫苗，同时大大减少生产时间和成本。VLP的未来应用始终受新兴技术和现代生活新要求的驱动。

更新日期：2018-03-21

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