The oxidation of pharmaceutical diclofenac (DCF) was investigated in a catalytic membrane reactor (CMR) comprising a tubular porous alumina (α-Al₂O₃) membrane, as support material, with embedded iron oxide nanoparticles (nFe) in situ generated in its pores. The performance of the heterogeneous Fenton-type oxidation reaction was examined in a laboratory-scale membrane pilot, with the addition of hydrogen peroxide. Aiming to optimize this CMR, Central Composite Design with Response Surface Methodology was employed to assess the effects of three key process parameters and their interaction on DCF degradation. Encouraging results were obtained, showing a significant DCF oxidation/mineralization by the α-Al₂O₃/nFe CMR. Feed solution pH was found to be the most significant variable, with acidic values leading to improved performance. Under near optimum operating conditions (pH 3 and 42.9 mg/L H₂O₂), the removal and mineralization of DCF was ∼65% and ∼48%, respectively. Negligible iron leaching was observed in the tests, which confirms the effective embedding and stability of catalytic nanoparticles in the ceramic porous matrix, thus allowing multiple membrane utilization. Future research directions are proposed towards method optimization, with emphasis given to membrane modification for improving the adsorption of organic pollutants and their oxidation within the catalytic membrane matrix.

药物双氯芬酸（DCF）中的氧化在催化膜反应器（CMR）包括管状多孔氧化铝进行了研究（α-Al系₂ ö ₃）膜，作为载体材料，以在原位产生嵌入的氧化铁纳米颗粒（NFE）其毛孔。在实验室规模的膜试验中，通过添加过氧化氢来检查非均相Fenton型氧化反应的性能。为了优化此CMR，采用带有响应面方法的中央复合设计来评估三个关键工艺参数及其对DCF降解的影响。获得令人鼓舞的结果，示出了由一个显著DCF氧化/矿化的α-Al ₂ ö ₃/ nFe CMR。发现进料溶液的pH是最重要的变量，其酸性值导致性能改善。在接近最佳操作条件（pH 3和42.9 mg / LH ₂ O ₂）下，DCF的去除率和矿化度分别为〜65％和〜48％。在测试中观察到微不足道的铁浸出，这证实了催化纳米颗粒在陶瓷多孔基质中的有效包埋和稳定性，从而允许多种膜的利用。提出了对方法优化的未来研究方向，重点是为了改进有机污染物的吸附及其在催化膜基质中的氧化而进行的膜改性。