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Photoredox/Cobalt-Catalyzed Phosphinyloxy Radical Addition/Cyclization Cascade: Synthesis of Phosphaisocoumarins
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2019-05-16 00:00:00 , DOI: 10.1021/acs.joc.9b00570
Ming-Ming Qiao 1 , Yi-Yin Liu 1 , Sheng Yao 1 , Tian-Cong Ma 1 , Zi-Long Tang 2 , De-Qing Shi 1 , Wen-Jing Xiao 1, 3
Affiliation  

A novel visible-light photoredox-catalyzed phosphinyloxy radical addition/cyclization cascade of arylphosphinic acids or arylphosphonic acid monoesters with alkynes has been developed, which provides an efficient and practical access to various phosphaisocoumarins by using a dual catalytic system containing an acridinium photosensitizer and a cobaloxime proton-reducing catalyst [Co(dmgH)2]PyCl at ambient temperature. This method has advantages of a broad substrate scope, mild condition, as well as no sacrificial oxidant.

中文翻译:

光氧化还原/钴催化的膦酰氧基自由基加成/环化级联:磷脂酰香豆素的合成

已开发出一种新型的可见光光氧化还原催化的芳基次膦酸或芳基膦酸单酯与炔烃的次膦酰氧基自由基加成/环化级联反应,通过使用包含a啶光敏剂和钴肟的双催化体系,可以有效而实用地获得各种磷杂香豆素。室温下质子还原催化剂[Co(dmgH )2 ] PyCl。该方法具有底物范围广,条件温和且无牺牲氧化剂的优点。
更新日期:2019-05-16
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