The elimination of metastases remains one of the major challenges in the curative treatment of patients with cancer. Therefore, most patients with metastatic disease typically receive systemic agents, which prolong survival and alleviate symptoms but are rarely curative. The oligometastatic paradigm challenges the prevailing view of metastasis as a disseminated process and proposes the existence of a spectrum of biological virulence within metastatic lesions. In this Perspectives article, we present evidence supporting our hypothesis that integrated clinical and molecular classification of metastases along the spectrum of disease influences the staging and treatment of patients with cancer.

转移的消除仍然是治愈癌症患者的主要挑战之一。因此，大多数转移性疾病患者通常接受全身性药物治疗，这些药物可延长生存期并减轻症状，但很少治愈。寡转移范式挑战了将转移作为扩散过程的主流观点，并提出了转移灶内存在一系列生物毒力。在此“观点”文章中，我们提供了支持我们假说的证据，即沿着疾病谱的转移的临床和分子综合分类会影响癌症患者的分期和治疗。