智能空心Pt-CuS Janus体系结构，用于协同催化增强的声动力学和光热癌症疗法。,Nano Letters

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智能空心Pt-CuS Janus体系结构，用于协同催化增强的声动力学和光热癌症疗法。
Nano Letters ( IF 9.6 ) Pub Date : 2019-05-17 , DOI: 10.1021/acs.nanolett.9b01595
Shuang Liang _{1,

2} , Xiaoran Deng _{1,

3} , Yun Chang _{1,

3} , Chunqiang Sun ₁ , Shuai Shao ₁ , Zhongxi Xie _{1,

2} , Xiao Xiao _{1,

2} , Ping'an Ma ₁ , Haiyuan Zhang _{1,

2} , Ziyong Cheng _{1,

2} , Jun Lin _{1,

2}

Affiliation

作为一种无创治疗手段，超声（US）触发的声动力学治疗（SDT）显示出广泛而有前途的应用，以克服传统的光动力学治疗（PDT）在抗击癌症中的弊端。但是，如果没有氧气（O2）的帮助，SDT的功效仍然不能令人满意。此外，还有很大的空间来探索基于SDT的协同治疗方式。在此，合理设计并成功合成了由中空半导体CuS和贵金属Pt组成的新型Pt-CuS Janus。中空的CuS显示出一个较大的内部空腔，用于装载声敏剂分子（四-（4-氨基苯基）卟啉，TAPP）以实现SDT。而且，由于局部电场增强的作用，Pt的沉积不仅比CuS纳米颗粒（NPs）增强了光热性能，而且还具有纳米酶活性，可催化内源性过表达的过氧化氢（H2O2）分解产生可克服的O2。肿瘤缺氧并增加SDT诱导的高毒性活性氧（ROS）产生，以有效地癌细胞凋亡。重要的是，通过808 nm激光辐照产生的Pt-CuS热量可以加速Pt的催化活性并提高O2含量，从而进一步促进SDT的功效。有趣的是，包覆在Janus周围的热敏共聚物可以充当智能开关，以调节Pt的催化能力并控制TAPP的释放，这对调节治疗效果具有重要作用。协同催化增强的SDT效率和高光热效应几乎实现了完整的肿瘤切除，没有明显的复发，同时还显示出高度的治疗生物安全性。此外，高的光吸收率允许合成的Pt-CuS Janus用于光声（PA）成像和NIR热成像。这项工作开发了一种多功能纳米治疗策略的通用纳米平台，并通过合理设计其结构来扩展生物学应用。协同催化增强的SDT效率和高光热效应几乎实现了完整的肿瘤切除，没有明显的复发，同时还显示出高度的治疗生物安全性。此外，高的光吸收率允许合成的Pt-CuS Janus用于光声（PA）成像和NIR热成像。这项工作开发了一种多功能纳米治疗策略的通用纳米平台，并通过合理设计其结构来扩展生物学应用。协同催化增强的SDT效率和高光热效应几乎实现了完整的肿瘤切除，没有明显的复发，同时还显示出高度的治疗生物安全性。此外，高的光吸收率允许合成的Pt-CuS Janus用于光声（PA）成像和NIR热成像。这项工作开发了一种多功能纳米治疗策略的通用纳米平台，并通过合理设计其结构来扩展生物学应用。

"点击查看英文标题和摘要"

Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy.

As a noninvasive treatment modality, ultrasound (US)-triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic therapy (PDT) in combating cancer. However, the SDT efficacy is still not satisfactory without oxygen (O2) assistance. In addition, there is also much space to explore the SDT-based synergistic therapeutic modalities. Herein, a novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized. The hollow CuS shows a large inner cavity for loading sonosensitizer molecules (tetra-(4-aminophenyl) porphyrin, TAPP) to implement SDT. Moreover, the deposition of Pt not only enhances photothermal performance compared with those of CuS nanoparticles (NPs) due to the effect of the local electric field enhancement but also possesses nanozyme activity for catalyzing decomposition of endogenous overexpressed hydrogen peroxide (H2O2) to produce O2 that can overcome tumor hypoxia and augment the SDT-induced highly toxic reactive oxygen species (ROS) production for efficient cancer cell apoptosis. Importantly, the generated heat of Pt-CuS by 808 nm laser irradiation can accelerate the catalytic activity of Pt and elevate the O2 level that further facilitates SDT efficacy. Interestingly, the thermally sensitive copolymer coated around the Janus can act as a smart switch to regulate the catalytic ability of Pt and control TAPP release that has a significant effect on modulating the therapeutic effect. The synergistic catalysis-enhanced SDT efficiency and highly photothermal effect almost realized complete tumor resection without obvious reoccurrence and simultaneously displayed a highly therapeutic biosafety. Furthermore, the high optical absorbance allows the as-synthesized Pt-CuS Janus for photoacoustic (PA) imaging and NIR thermal imaging. This work develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.

更新日期：2019-05-14

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