One Base for Two Shots: Metal-Free Substituent-Controlled Synthesis of Two Kinds of Oxadiazine Derivatives from Alkynylbenziodoxolones and Amidoximes,The Journal of Organic Chemistry

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One Base for Two Shots: Metal-Free Substituent-Controlled Synthesis of Two Kinds of Oxadiazine Derivatives from Alkynylbenziodoxolones and Amidoximes
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2019-05-14 00:00:00 , DOI: 10.1021/acs.joc.9b00659
Ming Li ₁ , Wei Li ₁ , Cheng-Dong Lin ₁ , Jia-Hui Wang ₁ , Li-Rong Wen ₁

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Different 1,2-migrations and cyclizations of a variety of alkynylbenziodoxolones (EBXs) and amidoximes under one-base conditions are described. This process provides an efficient protocol for the divergent synthesis of two oxadiazine derivatives via switchable selectivity of EBXs controlled by simply varying the substituents of the amidoximes, which feature transition metal-free conditions, simple execution, and high chemoselectivity.

中文翻译：

两枪的一个基础：由炔基苯并恶唑烷和酰胺基肟合成的两种恶二嗪衍生物的无金属取代基控制合成

描述了在一个碱基条件下，各种炔基苯并恶唑酮（EBXs）和ox胺肟的不同的1,2-迁移和环化。该方法为通过简单地改变the胺肟的取代基而控制的EBX的选择性切换提供了一种有效的方案，用于二恶二嗪衍生物的多样化合成，其特征在于无过渡金属的条件，简单的操作和高的化学选择性。

更新日期：2019-05-14

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