Surface Plasmon Platform for Angle-Resolved Chiral Sensing,ACS Photonics

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Surface Plasmon Platform for Angle-Resolved Chiral Sensing
ACS Photonics ( IF 6.5 ) Pub Date : 2019-05-14 00:00:00 , DOI: 10.1021/acsphotonics.9b00137
Sotiris Droulias ₁ , Lykourgos Bougas ₂

Affiliation

Chiral sensitive techniques have been used to probe the fundamental symmetries of the universe, study biomolecular structures, and even develop safe drugs. As chiral signals are inherently weak and often suppressed by large backgrounds, different techniques have been proposed to overcome the limitations of traditionally used chiral polarimetry. Here, we propose an angle-resolved chiral surface plasmon resonance (CHISPR) scheme that can detect the absolute chirality (handedness and magnitude) of a chiral sample and is sensitive to both the real and the imaginary part of a chiral sample’s refractive index. We present analytical results and numerical simulations of CHISPR measurements, predicting signals in the mdeg range for chiral samples of <100 nm thickness at visible wavelengths. Moreover, we present a theoretical analysis that clarifies how our far-field measurements elucidate the underlying physics. This CHISPR protocol does not require elaborate fabrication and has the advantage of being directly implementable on existing surface plasmon resonance instrumentation.

中文翻译：

用于角度分辨手性传感的表面等离激元平台

手性敏感技术已用于探测宇宙的基本对称性，研究生物分子结构，甚至开发安全的药物。由于手性信号固有地微弱并且经常被大背景抑制，因此已经提出了不同的技术来克服传统使用的手性极化法的局限性。在这里，我们提出了一种角度分辨手性表面等离子体共振（CHISPR）方案，该方案可以检测手性样品的绝对手性（手性和大小），并且对手性样品折射率的实部和虚部均敏感。我们提供了CHISPR测量的分析结果和数值模拟，可预测可见光波长下小于100 nm厚度的手性样品在mdeg范围内的信号。而且，我们提供了一种理论分析，阐明了我们的远场测量如何阐明基本物理原理。该CHISPR协议不需要复杂的制造，并且具有可直接在现有的表面等离振子共振仪器上实现的优势。

更新日期：2019-05-14

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