当前位置：
X-MOL 学术
›
ACS Appl. Nano Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
PEGylated β-NaGdF4/Tb@CaF2 Core/Shell Nanophosphors for Enhanced Radioluminescence and Folate Receptor Targeting
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2019-05-22 , DOI: 10.1021/acsanm.9b00629 Yufu Ren 1 , Hayden Winter 2 , Justin G. Rosch 1 , Kyungoh Jung 3 , Allison N. Duross 1 , Madeleine R. Landry 1 , Guillem Pratx 3 , Conroy Sun 1, 4
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2019-05-22 , DOI: 10.1021/acsanm.9b00629 Yufu Ren 1 , Hayden Winter 2 , Justin G. Rosch 1 , Kyungoh Jung 3 , Allison N. Duross 1 , Madeleine R. Landry 1 , Guillem Pratx 3 , Conroy Sun 1, 4
Affiliation
|
Lanthanide-doped nanocrystals have been examined extensively as contrast agents for various optical molecular imaging techniques. One of the greatest strengths of these nanomaterials is their ability to enable novel imaging modalities, such as X-ray excited radioluminescence imaging, which leverages the exceptional tissue depth penetration of X-rays and reduced tissue autofluorescence. Here, we report a uniquely engineered NaGdF4/Tb@CaF2 nanoscintillator with substantial lattice mismatch through integration of coprecipitation and thermal decomposition synthetic routes. We observed greatly enhanced radioluminescence by the NaGdF4/15%Tb@CaF2 core/shell nanocrystals, which results from the minimized surface quenching and localized structure transformation. Polyethylene glycol coated NaGdF4/15%Tb@CaF2 nanocrystals demonstrated robust aqueous colloidal stability and were well tolerated by a panel of cell lines. The core/shell NaGdF4/15%Tb@CaF2 nanophosphors were subsequently decorated with targeting folate ligands and investigated as an X-ray luminescence imaging probe in vitro. Overall, the results suggest that these optimized radioluminescent nanophosphors have the potential to enable X-ray excited optical emission for biological imaging and serve as energy mediators in theranostic applications.
中文翻译：
聚乙二醇化的β-NaGdF4/ Tb @ CaF2核/壳纳米磷光体，可增强放射发光和叶酸受体的靶向作用
掺杂镧系元素的纳米晶体已作为各种光学分子成像技术的造影剂得到了广泛的研究。这些纳米材料的最大优势之一是它们能够实现新颖的成像方式，例如X射线激发的放射发光成像，能够利用X射线出色的组织深度穿透力和减少的组织自发荧光。在这里，我们报告了通过共沉淀和热分解合成路线的整合，具有重大晶格失配的独特设计的NaGdF 4 / Tb @ CaF 2纳米闪烁体。我们观察到NaGdF 4 /15％Tb @ CaF 2大大增强了放射发光核/壳纳米晶体，这是由最小化的表面淬火和局部结构转变产生的。聚乙二醇涂覆的NaGdF 4 /15％Tb @ CaF 2纳米晶体表现出强大的水性胶体稳定性，并且被一组细胞系很好地耐受。随后用靶向叶酸配体修饰核/壳NaGdF 4 /15％Tb @ CaF 2纳米磷光体，并作为X射线发光成像探针进行了体外研究。总体而言，结果表明这些优化的放射发光纳米磷光体具有使X射线激发的光发射用于生物成像的潜力，并在诊断治疗应用中充当能量介体。
更新日期：2019-05-23
中文翻译：
聚乙二醇化的β-NaGdF4/ Tb @ CaF2核/壳纳米磷光体，可增强放射发光和叶酸受体的靶向作用
掺杂镧系元素的纳米晶体已作为各种光学分子成像技术的造影剂得到了广泛的研究。这些纳米材料的最大优势之一是它们能够实现新颖的成像方式，例如X射线激发的放射发光成像，能够利用X射线出色的组织深度穿透力和减少的组织自发荧光。在这里，我们报告了通过共沉淀和热分解合成路线的整合，具有重大晶格失配的独特设计的NaGdF 4 / Tb @ CaF 2纳米闪烁体。我们观察到NaGdF 4 /15％Tb @ CaF 2大大增强了放射发光核/壳纳米晶体，这是由最小化的表面淬火和局部结构转变产生的。聚乙二醇涂覆的NaGdF 4 /15％Tb @ CaF 2纳米晶体表现出强大的水性胶体稳定性，并且被一组细胞系很好地耐受。随后用靶向叶酸配体修饰核/壳NaGdF 4 /15％Tb @ CaF 2纳米磷光体，并作为X射线发光成像探针进行了体外研究。总体而言，结果表明这些优化的放射发光纳米磷光体具有使X射线激发的光发射用于生物成像的潜力，并在诊断治疗应用中充当能量介体。
京公网安备 11010802027423号