Generation of bioactive prolyl‐hydroxyproline (Pro‐Hyp) by oral administration of collagen hydrolysate and degradation of endogenous collagen,International Journal of Food Science & Technology

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Generation of bioactive prolyl‐hydroxyproline (Pro‐Hyp) by oral administration of collagen hydrolysate and degradation of endogenous collagen
International Journal of Food Science & Technology ( IF 2.6 ) Pub Date : 2019-05-09 , DOI: 10.1111/ijfs.14145
Kenji Sato ₁ , Shiro Jimi ₂ , Masashi Kusubata ₃

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Hydroxyproline‐containing di‐ and tripeptides increase in human blood plasma after ingestion of collagen hydrolysate in a dose‐dependent manner. Prolyl‐hydroxyproline (Pro‐Hyp) and hydroxyprolyl‐glycine (Pro‐Gly) are the main food‐derived collagen peptides present in human blood plasma. Pro‐Hyp increases the number of fibroblasts migrating from the mouse skin and enhances the growth of fibroblasts attached to the collagen gel. Pro‐Hyp is also generated from endogenous collagen in the granulation tissue in mice skin and ear with dermatitis, while it does not increase in the normal tissues of the same animal. However, Hyp‐Gly does not increase in all tissues. These facts indicate that Pro‐Hyp is generated by the degradation of endogenous collagen to activate cells involved in tissue reconstruction. Orally administered Pro‐Hyp is deposited in animal organs even after clearance of Pro‐Hyp from blood. Thus, the endogenous bioactive peptide can be provided by ingestion of collagen hydrolysate.

中文翻译：

通过口服胶原蛋白水解物和降解内源性胶原蛋白产生生物活性脯氨酰脯氨酸（Pro-Hyp）

摄入水解胶原蛋白后，血浆中含羟脯氨酸的二肽和三肽含量增加。脯氨酰脯氨酸（Pro-Hyp）和羟脯氨酰甘氨酸（Pro-Gly）是人血浆中主要的食物衍生胶原蛋白肽。Pro-Hyp增加了从小鼠皮肤迁移的成纤维细胞的数量，并增强了附着在胶原蛋白凝胶上的成纤维细胞的生长。Pro-Hyp也是由患有皮炎的小鼠皮肤和耳朵的肉芽组织中的内源性胶原蛋白产生的，而在同一只动物的正常组织中不会增加。但是，Hyp-Gly并非在所有组织中都增加。这些事实表明，Pro-Hyp是由内源性胶原降解以激活参与组织重建的细胞而产生的。即使将Pro-Hyp从血液中清除后，口服的Pro-Hyp也会沉积在动物器官中。因此，内源性生物活性肽可以通过摄取胶原蛋白水解产物来提供。

更新日期：2019-05-09

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