Quantitative Swab Touch Spray Mass Spectrometry for Oral Fluid Drug Testing.,Analytical Chemistry

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Quantitative Swab Touch Spray Mass Spectrometry for Oral Fluid Drug Testing.
Analytical Chemistry ( IF 6.7 ) Pub Date : 2019-05-10 00:00:00 , DOI: 10.1021/acs.analchem.9b01637
Nicolás M Morato ₁ , Valentina Pirro ₁ , Patrick W Fedick ₁ , R Graham Cooks ₁

Affiliation

Simultaneous determination of 30 common drugs of abuse, including opioids, benzodiazepines, fentanyl derivatives, methamphetamines, cocaine, substituted methylenedioxyphenethylamines, cathinones, antidepressants, and antipsychotics, in neat oral fluid was carried out using touch spray mass spectrometry from volumetric absorptive microsampling swabs. A simple and rapid (<2 min per sample) method using multiple reaction monitoring was developed and fully validated, yielding satisfactory analytical performance. Minimal sample volumes (10 μL) were used, and neither sample transfer nor preparation steps were required. Most detection limits were below 5 ng/mL from the complex drug mixture in the biological matrix. Simulations of in vivo sampling were carried out and acceptable quantitative results were obtained even under these conditions, indicating the potential of this technique for fast and noninvasive point-of-care drug testing in clinical or forensic settings.

中文翻译：

定量拭子接触喷雾质谱法，用于口服液体药物测试。

使用来自体积吸收微采样的接触喷雾质谱法同时测定纯净口服液中的30种常见滥用药物，包括阿片类药物，苯二氮卓类药物，芬太尼衍生物，甲基苯丙胺，可卡因，取代的亚甲基二氧苯乙胺，卡西酮，抗抑郁药和抗精神病药开发了一种简单快速的方法（每个样品<2分钟），使用了多反应监测，并进行了充分验证，从而产生令人满意的分析性能。使用最小的样品量（10μL），并且不需要样品转移或制备步骤。生物基质中复杂药物混合物的大多数检测限均低于5 ng / mL。进行了体内采样的模拟，即使在这些条件下也获得了可接受的定量结果，

更新日期：2019-05-10

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