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Redox-responsive blend hydrogel films based on carboxymethyl cellulose/chitosan microspheres as dual delivery carrier.
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2019-05-09 , DOI: 10.1016/j.ijbiomac.2019.05.049 Fang Wang 1 , Qian Zhang 1 , Xinxia Li 1 , Kexin Huang 1 , Wei Shao 1 , Dawei Yao 2 , Chaobo Huang 1
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2019-05-09 , DOI: 10.1016/j.ijbiomac.2019.05.049 Fang Wang 1 , Qian Zhang 1 , Xinxia Li 1 , Kexin Huang 1 , Wei Shao 1 , Dawei Yao 2 , Chaobo Huang 1
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A simple method to fabricate redox-responsive composite hydrogel films via incorporating chitosan (CS) microspheres into carboxymethyl cellulose (CMC) hydrogel using a di-sulphide cross-linker cystamine dihydrochloride (CYS) have done in this paper. Dual drugs, an anticancer, 5-Fluorouracil (5-FU) and an antibiotic, Tetracycline Hydrochloride (TH) were used as model drugs. The prepared composite hydrogel films were characterized using FTIR, SEM, rheology measurement, mechanical and swelling tests. Our results showed that the well dispersed spherical CS microspheres endowed hydrogel film increased mechanical properties and swellability. In vitro drug release displayed an accelerated release under weak acidic or reducing media. The in vitro cytotoxicity and cell apoptosis studies showed the drug-loaded composite film caused enhanced inhibition to HepG2 cells in presence of glutathione (GSH). Moreover, the film has exhibited excellent antimicrobial efficacy against E.coli and Staphylococcus aureus. Therefore, our simple and effective dual drug-loaded system has the potential to be used for cancer therapy in the future.
中文翻译：
基于羧甲基纤维素/壳聚糖微球作为双重递送载体的氧化还原反应性混合水凝胶薄膜。
本文通过使用二硫化物交联剂胱胺二盐酸盐（CYS）将壳聚糖（CS）微球掺入羧甲基纤维素（CMC）水凝胶中来制备氧化还原响应性复合水凝胶薄膜的简单方法。模型药物使用双重药物：抗癌药物5-氟尿嘧啶（5-FU）和抗生素四环素盐酸盐（TH）。使用FTIR，SEM，流变学测量，机械和溶胀测试对制备的复合水凝胶薄膜进行表征。我们的结果表明，分散良好的球形CS微球赋予水凝胶膜可提高机械性能和可溶胀性。体外药物释放在弱酸性或还原性介质下显示出加速释放。体外细胞毒性和细胞凋亡研究表明，在谷胱甘肽（GSH）存在的情况下，载有药物的复合膜对HepG2细胞的抑制作用增强。而且，该膜对大肠杆菌和金黄色葡萄球菌显示出优异的抗微生物功效。因此，我们简单有效的双重药物加载系统有可能在将来用于癌症治疗。
更新日期：2019-05-09
中文翻译：
基于羧甲基纤维素/壳聚糖微球作为双重递送载体的氧化还原反应性混合水凝胶薄膜。
本文通过使用二硫化物交联剂胱胺二盐酸盐（CYS）将壳聚糖（CS）微球掺入羧甲基纤维素（CMC）水凝胶中来制备氧化还原响应性复合水凝胶薄膜的简单方法。模型药物使用双重药物：抗癌药物5-氟尿嘧啶（5-FU）和抗生素四环素盐酸盐（TH）。使用FTIR，SEM，流变学测量，机械和溶胀测试对制备的复合水凝胶薄膜进行表征。我们的结果表明，分散良好的球形CS微球赋予水凝胶膜可提高机械性能和可溶胀性。体外药物释放在弱酸性或还原性介质下显示出加速释放。体外细胞毒性和细胞凋亡研究表明，在谷胱甘肽（GSH）存在的情况下，载有药物的复合膜对HepG2细胞的抑制作用增强。而且，该膜对大肠杆菌和金黄色葡萄球菌显示出优异的抗微生物功效。因此，我们简单有效的双重药物加载系统有可能在将来用于癌症治疗。
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