Gold-Nanoparticle-Assisted Plasmonic Photothermal Therapy Advances Toward Clinical Application,The Journal of Physical Chemistry C

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Gold-Nanoparticle-Assisted Plasmonic Photothermal Therapy Advances Toward Clinical Application
The Journal of Physical Chemistry C ( IF 3.3 ) Pub Date : 2019-05-28 , DOI: 10.1021/acs.jpcc.9b01961
Moustafa R. K. Ali ₁ , Yue Wu ₁ , Mostafa A. El-Sayed ₁

Affiliation

Plasmonic photothermal therapy (PPTT), a type of treatment involving the intravenous or intratumoral injection to introduce gold nanoparticles to cancerous cells and the subsequent exposure to heat-generating near-infrared (NIR) light, is a potentially favorable alternative to traditional treatments of localized tumors such as chemotherapy, radiotherapy, and surgery. The current main concern of PPTT, however, is the feasibility of the treatment in clinical settings. Since PPTT’s initial use 15 years ago, thousands of studies have been published. In this feature article, we summarize the most recent scientific progress, including the efficacy, molecular mechanism, toxicity, and pharmacokinetics of PPTT in vitro with cancer cells and in vivo through mouse/rat model testing, animal clinical cases (such as dogs and cats), and human clinical trials. Given the benefits of PPTT, we believe that it will ultimately become a human clinical treatment that can aid in our ultimate goal of beating cancer.

中文翻译：

金纳米粒子辅助的等离子光热疗法朝着临床应用的方向发展。

等离子光热疗法（PPTT）是一种治疗方法，它涉及通过静脉内或肿瘤内注射将金纳米颗粒引入癌细胞，然后暴露于发热的近红外（NIR）光中，是对局部治疗的传统治疗的潜在有利替代方法肿瘤，例如化学疗法，放射疗法和手术。然而，PPTT当前主要关注的是在临床环境中进行治疗的可行性。自从15年前PPTT首次使用以来，已经发表了数千篇研究报告。在这篇专题文章中，我们总结了最新的科学进展，包括PPTT在癌细胞和体内的体外功效，分子机制，毒性和药代动力学通过小鼠/大鼠模型测试，动物临床案例（例如狗和猫）以及人类临床试验。有了PPTT的好处，我们相信它将最终成为一种人类临床治疗方法，可以帮助我们战胜癌症的最终目标。

更新日期：2019-05-28

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