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Widespread Utilization of Peptide Communication in Phages Infecting Soil and Pathogenic Bacteria.
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2019-05-08 , DOI: 10.1016/j.chom.2019.03.017 Avigail Stokar-Avihail 1 , Nitzan Tal 1 , Zohar Erez 1 , Anna Lopatina 1 , Rotem Sorek 1
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2019-05-08 , DOI: 10.1016/j.chom.2019.03.017 Avigail Stokar-Avihail 1 , Nitzan Tal 1 , Zohar Erez 1 , Anna Lopatina 1 , Rotem Sorek 1
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Temperate phages can adopt either a lytic or lysogenic lifestyle within their host bacteria. It was recently shown that Bacillus-subtilis-infecting phages of the SPbeta group utilize a peptide-based communication system called arbitrium to coordinate the lysogeny decision. The occurrence of peptide-based communication systems among phages more broadly remains to be explored. Here, we uncover a wide array of peptide-based communication systems utilized by phages for lysogeny decisions. These arbitrium-like systems show diverse peptide codes and can be detected in numerous genetically distant phage types and conjugative elements. The pathogens Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis are commonly infected by arbitrium-carrying mobile elements, which often carry toxins essential for pathogenicity. Experiments with phages containing these arbitrium-like systems demonstrate their involvement in lysogeny decisions. Finally, our results suggest that the peptide-based decision is executed by an antisense RNA that controls the regulator of the lysogenic state.
中文翻译：
肽在感染土壤和致病细菌的噬菌体中的广泛利用。
温带噬菌体可以在其宿主细菌中采用裂解或溶原性生活方式。最近显示，SPbeta组的枯草芽孢杆菌感染噬菌体利用称为arbitrium的基于肽的通讯系统来协调溶菌性决定。噬菌体中基于肽的通讯系统的发生更广泛地尚待探索。在这里，我们发现了噬菌体用于溶源性决定的各种基于肽的通讯系统。这些类似arbitrium的系统显示出不同的肽密码，可以在许多遗传距离较远的噬菌体类型和结合元件中检测到。病原体炭疽杆菌，蜡状芽孢杆菌和苏云金芽孢杆菌通常被携带携带Arbitrium的移动元件感染，这些元件通常携带对致病性必不可少的毒素。含有这些类似类Arbitrium系统的噬菌体的实验表明，它们参与了溶菌原性决定。最后，我们的结果表明，基于肽的决定是由控制溶源性状态调节剂的反义RNA执行的。
更新日期：2019-05-16
中文翻译：
肽在感染土壤和致病细菌的噬菌体中的广泛利用。
温带噬菌体可以在其宿主细菌中采用裂解或溶原性生活方式。最近显示，SPbeta组的枯草芽孢杆菌感染噬菌体利用称为arbitrium的基于肽的通讯系统来协调溶菌性决定。噬菌体中基于肽的通讯系统的发生更广泛地尚待探索。在这里，我们发现了噬菌体用于溶源性决定的各种基于肽的通讯系统。这些类似arbitrium的系统显示出不同的肽密码，可以在许多遗传距离较远的噬菌体类型和结合元件中检测到。病原体炭疽杆菌，蜡状芽孢杆菌和苏云金芽孢杆菌通常被携带携带Arbitrium的移动元件感染，这些元件通常携带对致病性必不可少的毒素。含有这些类似类Arbitrium系统的噬菌体的实验表明，它们参与了溶菌原性决定。最后，我们的结果表明，基于肽的决定是由控制溶源性状态调节剂的反义RNA执行的。
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