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Circulating tumor cells undergoing EMT are poorly correlated with clinical stages or predictive of recurrence in hepatocellular carcinoma.
Scientific Reports ( IF 3.8 ) Pub Date : 2019-05-08 , DOI: 10.1038/s41598-019-43572-1 Yunyang Chen 1 , Shaoming Li 1 , Wei Li 1 , Rongbing Yang 1 , Xianguang Zhang 1 , Yong Ye 1 , Jiexiong Yu 1 , Lin Ye 1 , Wangrong Tang 1
Scientific Reports ( IF 3.8 ) Pub Date : 2019-05-08 , DOI: 10.1038/s41598-019-43572-1 Yunyang Chen 1 , Shaoming Li 1 , Wei Li 1 , Rongbing Yang 1 , Xianguang Zhang 1 , Yong Ye 1 , Jiexiong Yu 1 , Lin Ye 1 , Wangrong Tang 1
Affiliation
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Experimental and clinical studies have highlighted that circulating tumor cell (CTC) with phenotypic hallmarks of epithelial-mesenchymal transition (EMT) plays a critical role in the metastatic and recurrence of solid malignancy. Here we retrospectively evaluated the presence of CTC and its EMT phenotypes in hepatocellular carcinoma (HCC) patients and investigated their clinical relevance. We optimized the CanpatrolTM CTC analysis system to enumerate CTC and classify EMT phenotypes in 113 HCC patients before curative treatment and 143 HCC patients after curative treatment. The relationships between CTC and clinical characteristics were statistically analyzed. None of total CTC or its EMT phenotypes in HCC patients was correlated with clinical characteristics, such as age, sex, HBsAg, Child-Pugh score, liver cirrhosis, AFP, number of tumors, tumor size, vascular invasion and BCLC stage. Neither the level of total CTC nor its EMT phenotypes in HCC patients before or after curative treatment were predictive of recurrence. Additionally, dynamic changes of CTC and its EMT phenotypes were not relevant to HCC recurrence after curative treatment in our study. Wefound CTC count and EMT classification were not correlated with clinical stages or predictive of HCC recurrence, but further large, multicenter studies are needed to confirm these results.
中文翻译：
进行EMT的循环肿瘤细胞与肝癌的临床分期或预后不良相关。
实验和临床研究强调，具有上皮-间质转化（EMT）的表型特征的循环肿瘤细胞（CTC）在实体恶性肿瘤的转移和复发中起关键作用。在这里，我们回顾性评估肝细胞癌（HCC）患者中CTC及其EMT表型的存在，并调查其临床相关性。我们优化了CanpatrolTM CTC分析系统，以对113例治疗前的HCC患者和143例治疗后的HCC患者进行CTC计数和EMT表型分类。统计分析CTC与临床特征之间的关系。HCC患者的总CTC或其EMT表型均与年龄，性别，HBsAg，Child-Pugh评分，肝硬化，AFP，肿瘤数目，肿瘤大小，血管侵犯和BCLC分期。治愈之前或之后，HCC患者的总CTC水平及其EMT表型均不能预测复发。此外，在我们的研究中，治疗后CTC及其EMT表型的动态变化与HCC复发无关。我们发现CTC计数和EMT分类与临床分期或HCC复发的预测无关，但是需要进一步的大型多中心研究来证实这些结果。
更新日期：2019-05-16
中文翻译：
进行EMT的循环肿瘤细胞与肝癌的临床分期或预后不良相关。
实验和临床研究强调，具有上皮-间质转化（EMT）的表型特征的循环肿瘤细胞（CTC）在实体恶性肿瘤的转移和复发中起关键作用。在这里，我们回顾性评估肝细胞癌（HCC）患者中CTC及其EMT表型的存在，并调查其临床相关性。我们优化了CanpatrolTM CTC分析系统，以对113例治疗前的HCC患者和143例治疗后的HCC患者进行CTC计数和EMT表型分类。统计分析CTC与临床特征之间的关系。HCC患者的总CTC或其EMT表型均与年龄，性别，HBsAg，Child-Pugh评分，肝硬化，AFP，肿瘤数目，肿瘤大小，血管侵犯和BCLC分期。治愈之前或之后，HCC患者的总CTC水平及其EMT表型均不能预测复发。此外，在我们的研究中，治疗后CTC及其EMT表型的动态变化与HCC复发无关。我们发现CTC计数和EMT分类与临床分期或HCC复发的预测无关，但是需要进一步的大型多中心研究来证实这些结果。
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