Bergapten, a furanocoumarin derivative found in a variety of medicinal plants, is documented to possess anti-inflammatory activity. However, whether bergapten is useful in alleviating the symptoms as well as the progress of peripheral neuropathy is not yet studied. The current investigation has been designed to explore the effect of bergapten on vincristine-induced neuropathic pain. Rats were grouped as normal, neuropathic control (vincristine), gabapentin, and bergapten treated groups with five animals in each group. Vincristine (100 μg/kg, i.p.) was administered for 10 days with 2 days break. Gabapentin (60 mg/kg, i.p.) and bergapten (10 mg/kg i.p.) treatments were given once daily for 14 days. The animals were assessed for hyperalgesia and allodynia. After 14 days, animals were sacrificed to detect plasma pro-inflammatory cytokines (TNF α, IL-1β), spinal cord, and sciatic nerve oxidative stress and expression of iNOS, COX-2, and NFkB in the spinal cord. There was a marked reduction in pain behaviors in the bergapten group as compared to the vincristine group. Bergapten also attenuated pro-inflammatory cytokines (TNFα and IL-1β), oxidative stress, and expression of NFkB, COX-2, and iNOS. Overall the current study concludes that bergapten could serve as a potential lead to drug development for the treatment of neuropathic pain.

中文翻译：

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Bergapten通过抑制炎性细胞因子和NFκB信号传导改善长春新碱诱导的周围神经病变。

Bergapten是一种在多种药用植物中发现的呋喃香豆素衍生物，据报道具有抗炎活性。然而，尚未研究佛手柑是否可用于减轻症状以及周围神经病变的进展。当前的研究旨在探讨香精中长春新碱对长春新碱引起的神经性疼痛的作用。将大鼠分为正常，神经病理对照（长春新碱），加巴喷丁和佛手柑治疗组，每组五只动物。给予长春新碱（100μg/ kg，ip）10天，休息2天。加巴喷丁（60 mg / kg，腹腔内）和bergapten（10 mg / kg腹膜内）每天治疗一次，共14天。评估动物的痛觉过敏和异常性疼痛。14天后，处死动物以检测血浆促炎细胞因子（TNFα，IL-1β），脊髓和坐骨神经氧化应激以及脊髓中iNOS，COX-2和NFkB的表达。与长春新碱组相比，佛手柑组的疼痛行为明显减少。Bergapten还减弱了促炎细胞因子（TNFα和IL-1β），氧化应激以及NFkB，COX-2和iNOS的表达。总的来说，当前的研究得出结论，佛手柑可以作为治疗神经性疼痛的药物开发的潜在先导。