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Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency.
Scientific Reports ( IF 3.8 ) Pub Date : 2019-05-03 , DOI: 10.1038/s41598-019-42186-x
Mengxiang Zhu 1, 2 , Yingying Wang 1 , Gaia Ferracci 3 , Jing Zheng 1, 2 , Nam-Joon Cho 3 , Bae Hoon Lee 1, 2
Scientific Reports ( IF 3.8 ) Pub Date : 2019-05-03 , DOI: 10.1038/s41598-019-42186-x
Mengxiang Zhu 1, 2 , Yingying Wang 1 , Gaia Ferracci 3 , Jing Zheng 1, 2 , Nam-Joon Cho 3 , Bae Hoon Lee 1, 2
Affiliation
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Gelatin methacryloyl (GelMA) is a versatile material for a wide range of bioapplications. There is an intense interest in developing effective chemical strategies to prepare GelMA with a high degree of batch-to-batch consistency and controllability in terms of methacryloyl functionalization and physiochemical properties. Herein, we systematically investigated the batch-to-batch reproducibility and controllability of producing GelMA (target highly and lowly substituted versions) via a one-pot strategy. To assess the GelMA product, several parameters were evaluated, including the degree of methacryloylation, secondary structure, and enzymatic degradation, along with the mechanical properties and cell viability of GelMA hydrogels. The results showed that two types of target GelMA with five batches exhibited a high degree of controllability and reproducibility in compositional, structural, and functional properties owing to the highly controllable one-pot strategy.
中文翻译:
明胶甲基丙烯酰基及其水凝胶具有出色的可控性和批次间一致性。
明胶甲基丙烯酰基(GelMA)是用于多种生物应用的通用材料。人们对开发有效的化学策略以制备甲基丙烯酸丙烯酰官能化和理化性质具有高度批次间一致性和可控性的GelMA有着浓厚的兴趣。在这里,我们系统地研究了通过一锅法生产GelMA(目标高和低取代版本)的批次间可重复性和可控性。为了评估GelMA产品,评估了几个参数,包括甲基丙烯酰化程度,二级结构和酶促降解,以及GelMA水凝胶的机械性能和细胞生存力。
更新日期:2019-05-03
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
明胶甲基丙烯酰基及其水凝胶具有出色的可控性和批次间一致性。
明胶甲基丙烯酰基(GelMA)是用于多种生物应用的通用材料。人们对开发有效的化学策略以制备甲基丙烯酸丙烯酰官能化和理化性质具有高度批次间一致性和可控性的GelMA有着浓厚的兴趣。在这里,我们系统地研究了通过一锅法生产GelMA(目标高和低取代版本)的批次间可重复性和可控性。为了评估GelMA产品,评估了几个参数,包括甲基丙烯酰化程度,二级结构和酶促降解,以及GelMA水凝胶的机械性能和细胞生存力。