Arginyl-fructosyl-glucose, a Major Maillard Reaction Product of Red Ginseng, Attenuates Cisplatin-Induced Acute Kidney Injury by Regulating Nuclear Factor κB and Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathways,Journal of Agricultural and Food Chemistry

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Arginyl-fructosyl-glucose, a Major Maillard Reaction Product of Red Ginseng, Attenuates Cisplatin-Induced Acute Kidney Injury by Regulating Nuclear Factor κB and Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathways
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2019-05-02 00:00:00 , DOI: 10.1021/acs.jafc.9b00540
Rong-yan Li ₁ , Wei-zhe Zhang ₁ , Xiao-tong Yan ₁ , Jin-gang Hou _{1,

2} , Zi Wang _{1,

3} , Chuan-bo Ding ₁ , Wen-cong Liu _{1,

3} , Yi-nan Zheng ₁ , Chen Chen ₄ , Yue-ru Li ₁ , Wei Li _{1,

3}

Affiliation

Recently, although ginseng (Panax ginseng C. A. Meyer) and its main component saponins (ginsenosides) have been reported to exert protective effects on cisplatin (CDDP)-induced acute kidney injury (AKI), the beneficial activities of non-saponin on CDDP-induced AKI is little known. This research was designed to explore the protective effect and underlying mechanism of arginyl-fructosyl-glucose (AFG), a major and representative non-saponin component generated during the process of red ginseng, on CDDP-caused AKI. AFG at doses of 40 and 80 mg/kg remarkably reversed CDDP-induced renal dysfunction, accompanied by the decreased levels of serum creatinine and blood urea nitrogen. Interestingly, all of oxidative stress indices were ameliorated after pretreatment with AFG continuously for 10 days. Importantly, AFG relieved CDDP-induced inflammation and apoptosis in part by mitigating the cascade initiation steps of nuclear factor κB signals and regulating the participation of the phosphatidylinositol 3-kinase/protein kinase B signal pathway. In conclusion, these results clearly provide strong rationale for the development of AFG to prevent CDDP-induced AKI.

中文翻译：

红参的主要美拉德反应产物精氨酸-果糖基-葡萄糖可通过调节核因子κB和磷脂酰肌醇3-激酶/蛋白激酶B的信号传导途径减轻顺铂引起的急性肾脏损伤。

最近，虽然人参（人参据报道，CA Meyer及其主要成分皂苷（人参皂甙）对顺铂（CDDP）诱导的急性肾损伤（AKI）具有保护作用，而非皂苷对CDDP诱导的AKI的有益作用鲜为人知。这项研究旨在探讨精氨酸-果糖基-葡萄糖（AFG）对人参DPK引起的AKI的保护作用和潜在机理，AFG是红参过程中产生的主要和代表性非皂苷成分。AFG剂量为40和80 mg / kg时，可明显逆转CDDP诱导的肾功能不全，并伴有血清肌酐和血尿素氮水平的降低。有趣的是，在连续10天用AFG预处理后，所有的氧化应激指数都得到了改善。重要的，AFG通过减轻核因子κB信号的级联起始步骤和调节磷脂酰肌醇3激酶/蛋白激酶B信号通路的参与来缓解CDDP诱导的炎症和细胞凋亡。总之，这些结果显然为AFG预防CDDP引起的AKI的发展提供了有力的依据。

更新日期：2019-05-02

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