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Self-adhesive photothermal hydrogel films for solar-light assisted wound healing†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-05-01 00:00:00 , DOI: 10.1039/c9tb00481e Yujie Gao 1, 2, 3, 4, 5 , Hongyao Du 6, 7, 8, 9, 10 , Zhanjun Xie 1, 2, 3, 4, 5 , Miaomiao Li 1, 2, 3, 4, 5 , Jinjin Zhu 6, 7, 8, 9, 10 , Jingwei Xu 1, 2, 3, 4, 5 , Lianbin Zhang 1, 2, 3, 4, 5 , Juan Tao 6, 7, 8, 9, 10 , Jintao Zhu 1, 2, 3, 4, 5
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-05-01 00:00:00 , DOI: 10.1039/c9tb00481e Yujie Gao 1, 2, 3, 4, 5 , Hongyao Du 6, 7, 8, 9, 10 , Zhanjun Xie 1, 2, 3, 4, 5 , Miaomiao Li 1, 2, 3, 4, 5 , Jinjin Zhu 6, 7, 8, 9, 10 , Jingwei Xu 1, 2, 3, 4, 5 , Lianbin Zhang 1, 2, 3, 4, 5 , Juan Tao 6, 7, 8, 9, 10 , Jintao Zhu 1, 2, 3, 4, 5
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Hydrogel-based dressings can provide a moist environment for wounds, and have been proven to be beneficial for wound healing. However, preparation of effective hydrogel dressings in a facile yet robust manner still remains a big challenge. Herein, a photo-initiated polymerization method is employed to develop a photothermal hydrogel film with self-adhesive properties for accelerated wound healing under solar light irradiation. Such a hydrogel film is obtained by taking advantage of the excellent adhesion of bioinspired polydopamine (PDA) and the great photothermal conversion capability of reduced graphene oxide (rGO) upon solar light irradiation. The formed photothermal hydrogel film could adhere to wounds and convert solar light into heat, warming up the wound locally. The localized temperature enhancement significantly promotes wound healing by reducing the inflammatory response, and enhancing re-epithelialization, angiogenesis, and collagen deposition, presumably correlated with the increased expressions of transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor-A (VEGF-A). This finding demonstrates the great potential of the photothermal hydrogel film for wound healing in clinical or daily applications.
中文翻译：
用于太阳光辅助伤口愈合的自粘光热水凝胶薄膜†
基于水凝胶的敷料可为伤口提供湿润的环境，并已被证明对伤口愈合有益。然而，以简便而稳固的方式制备有效的水凝胶敷料仍然是一个巨大的挑战。在本文中，采用光引发的聚合方法来开发具有自粘性的光热水凝胶膜，以在太阳光照射下加速伤口愈合。这种水凝胶膜是通过利用生物启发的聚多巴胺（PDA）的出色附着力以及在太阳光照射下还原的氧化石墨烯（rGO）的强大的光热转化能力而获得的。形成的光热水凝胶膜可能粘附在伤口上，并将太阳光转化为热量，从而局部加热伤口。局部温度升高通过减少炎症反应，增强再上皮形成，血管生成和胶原蛋白沉积而显着促进伤口愈合，可能与转化生长因子-β1（TGF-β1）和血管内皮生长因子-A的表达增加有关（VEGF-A）。该发现证明了光热水凝胶膜在临床或日常应用中对伤口愈合的巨大潜力。
更新日期：2019-05-01
中文翻译：
用于太阳光辅助伤口愈合的自粘光热水凝胶薄膜†
基于水凝胶的敷料可为伤口提供湿润的环境，并已被证明对伤口愈合有益。然而，以简便而稳固的方式制备有效的水凝胶敷料仍然是一个巨大的挑战。在本文中，采用光引发的聚合方法来开发具有自粘性的光热水凝胶膜，以在太阳光照射下加速伤口愈合。这种水凝胶膜是通过利用生物启发的聚多巴胺（PDA）的出色附着力以及在太阳光照射下还原的氧化石墨烯（rGO）的强大的光热转化能力而获得的。形成的光热水凝胶膜可能粘附在伤口上，并将太阳光转化为热量，从而局部加热伤口。局部温度升高通过减少炎症反应，增强再上皮形成，血管生成和胶原蛋白沉积而显着促进伤口愈合，可能与转化生长因子-β1（TGF-β1）和血管内皮生长因子-A的表达增加有关（VEGF-A）。该发现证明了光热水凝胶膜在临床或日常应用中对伤口愈合的巨大潜力。
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