当前位置: X-MOL 学术Synthesis › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Direct Synthesis of Deuterium-Labeled O-, S-, N-Vinyl Derivatives from Calcium Carbide
Synthesis ( IF 2.2 ) Pub Date : 2019-04-30 , DOI: 10.1055/s-0037-1611518
Maria S. Ledovskaya 1 , Vladimir V. Voronin 1 , Konstantin S. Rodygin 1, 2 , Alexandra V. Posvyatenko 2, 3, 4 , Ksenia S. Egorova 2 , Valentine P. Ananikov 1, 2
Affiliation  

Abstract

A novel methodology for the preparation of trideuterovinyl derivatives of high purity directly from alcohols, thiols, and NH-compounds was developed. Commercially available calcium carbide and D2O acted as a D2-acetylene source, and DMSO-d 6 was used to complete the formation of the D2C=C(D)–X fragment (X = O, S, N). Polymerization of a selected trideuterovinylated compound showed a very promising potential of these substances in the synthesis of labeled polymeric materials. Biological activity of the synthesized trideuterovinyl derivatives was evaluated and the results indicated a significant increase of cytotoxicity upon deuteration.

A novel methodology for the preparation of trideuterovinyl derivatives of high purity directly from alcohols, thiols, and NH-compounds was developed. Commercially available calcium carbide and D2O acted as a D2-acetylene source, and DMSO-d 6 was used to complete the formation of the D2C=C(D)–X fragment (X = O, S, N). Polymerization of a selected trideuterovinylated compound showed a very promising potential of these substances in the synthesis of labeled polymeric materials. Biological activity of the synthesized trideuterovinyl derivatives was evaluated and the results indicated a significant increase of cytotoxicity upon deuteration.



中文翻译:

由碳化钙直接合成氘标记的O-,S-,N-乙烯基衍生物

抽象的

开发了一种直接从醇,硫醇和NH-化合物直接制备高纯度的三氘代戊二烯衍生物的新颖方法。市售电石和D 2 O充当D 2-乙炔源,而DMSO- d 6用于完成D 2 C = C(D)–X片段的形成(X = O,S,N) 。所选的三氘代戊二酰化化合物的聚合显示这些物质在标记聚合物材料的合成中具有非常有希望的潜力。评价了合成的三氘代戊二酰基衍生物的生物活性,结果表明,氘化后细胞毒性显着增加。

开发了一种直接从醇,硫醇和NH-化合物直接制备高纯度的三氘代戊二烯衍生物的新颖方法。市售电石和D 2 O充当D 2-乙炔源,而DMSO- d 6用于完成D 2 C = C(D)–X片段的形成(X = O,S,N) 。所选的三氘代戊二酰化化合物的聚合显示这些物质在标记聚合物材料的合成中具有非常有希望的潜力。评价了合成的三氘代戊二酰基衍生物的生物活性,结果表明,氘化后细胞毒性显着增加。

更新日期:2019-04-30
down
wechat
bug