Synthesis ( IF 2.2 ) Pub Date : 2019-04-30 , DOI: 10.1055/s-0037-1611528
Qinghe Wang 1 , Dulin Kong 2 , Tiao Huang 1 , Mingshu Wu 1
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Abstract
An efficient synthetic strategy for anti-3,4-disubstituted phosphadihydrocoumarin compounds has been established by tandem aza-Michael–aldol-like annulations of tetrahydroisoquinolines with O-vinylphosphonylated salicylaldehydes as an aldo-vinyl bifunctional building block. This conversion was characterized by ‘green’ properties such as a step- and atom-economy, catalyst-free conditions, highly anti-selectivity, and readily available starting materials.
An efficient synthetic strategy for anti-3,4-disubstituted phosphadihydrocoumarin compounds has been established by tandem aza-Michael–aldol-like annulations of tetrahydroisoquinolines with O-vinylphosphonylated salicylaldehydes as an aldo-vinyl bifunctional building block. This conversion was characterized by ‘green’ properties such as a step- and atom-economy, catalyst-free conditions, highly anti-selectivity, and readily available starting materials.
中文翻译：
O-乙烯基膦酰基化的水杨醛作为抗3,4-二取代的磷酸二氢香豆素的Aldo-乙烯基双功能构建基块
抽象的
对于一种有效的合成策略的抗-3,4-二取代phosphadihydrocoumarin化合物已经通过串联建立氮杂-迈克尔羟醛状四氢异喹啉的annulations与ö -vinylphosphonylated水杨醛作为醛-乙烯基双功能构建块。该转化的特征在于“绿色”性质，例如步阶和原子经济，无催化剂条件，高度抗选择性和易于获得的起始原料。
对于一种有效的合成策略的抗-3,4-二取代phosphadihydrocoumarin化合物已经通过串联建立氮杂-迈克尔羟醛状四氢异喹啉的annulations与ö -vinylphosphonylated水杨醛作为醛-乙烯基双功能构建块。该转化的特征在于“绿色”性质，例如步阶和原子经济，无催化剂条件，高度抗选择性和易于获得的起始原料。
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