Expression of the Tim3‐Galectin 9 axis is altered in drug‐induced maculopapular exanthema,Allergy

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Expression of the Tim3‐Galectin 9 axis is altered in drug‐induced maculopapular exanthema
Allergy ( IF 12.6 ) Pub Date : 2019-05-31 , DOI: 10.1111/all.13847
Ruben Fernandez-Santamaría ₁ , Francisca Palomares ₁ , Maria Salas _{1,

2} , Inmaculada Doña _{1,

2} , Gador Bogas _{1,

2} , Adriana Ariza ₁ , Alba Rodriguez-Nogales ₁ , Maria C Plaza-Seron ₁ , Cristobalina Mayorga _{1,

2} , Maria J Torres _{1,

2,

3} , Tahia D Fernández ₁

Affiliation

Drug‐induced maculopapular exanthemas (MPEs) are mediated by Th1 CD4+ T cells. One of the mechanisms of control of Th1 cells in homeostasis is the interaction between the checkpoint inhibitor Tim3 and its physiological ligand galectin‐9 (Gal9). Disorders affecting this axis may be responsible for various autoimmune and immunological diseases. The aim of this study was to determinate the influence of the Tim3‐Gal9 axis on the development of MPE induced by drugs.

中文翻译：

Tim3-Galectin 9 轴的表达在药物诱导的黄斑丘疹中发生改变

药物诱导的黄斑丘疹 (MPE) 由 Th1 CD4+ T 细胞介导。体内平衡中控制 Th1 细胞的机制之一是检查点抑制剂 Tim3 与其生理配体 galectin-9 (Gal9) 之间的相互作用。影响该轴的疾病可能是导致各种自身免疫和免疫疾病的原因。本研究的目的是确定 Tim3-Gal9 轴对药物诱导的 MPE 发展的影响。

更新日期：2019-05-31

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