Characterization of Crocetin‐Monoglucuronide as a Neuron‐Protective Metabolite of Crocin‐1,Molecular Nutrition & Food Research

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Characterization of Crocetin‐Monoglucuronide as a Neuron‐Protective Metabolite of Crocin‐1
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2019-05-21 , DOI: 10.1002/mnfr.201900024
Anyun Zhu ₁ , Chuyu Lao ₂ , Ze Wang ₁ , Yang Chen ₁ , Chuan Bai ₃

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Crocins are important apocarotenoids in the extract of saffron (Crocus sativus L.) and fruits of gardenia (Gardenia jasminoides E.). Crocins have shown versatile biological activities and thus they have been considered to be promising therapeutics for neurodegenerative and heart diseases. Metabolism studies report that crocetin‐monoglucuronide (CM) is produced and detected in rat blood plasma after oral administration of crocins. However, due to the lack of standard compound of CM, its unambiguous identification, quantification, and bioactivity studies have been hindered.

中文翻译：

作为藏红花素-1 神经元保护代谢物的藏花酸-单葡糖苷酸的表征

藏红花素是藏红花 ( Crocus sativus L.) 和栀子 ( Gardenia jasminoides E.) 提取物中重要的类胡萝卜素。藏红花素已显示出多种生物活性，因此它们被认为是治疗神经退行性疾病和心脏病的有前途的药物。代谢研究报告说，口服藏红花素后会在大鼠血浆中产生并检测到藏红花酸单葡糖苷酸 (CM)。然而，由于缺乏CM的标准化合物，其明确的鉴定、定量和生物活性研究一直受到阻碍。

更新日期：2019-05-21

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