Hydroalkylation of Olefins to form Quaternary Carbons,Journal of the American Chemical Society

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Hydroalkylation of Olefins to form Quaternary Carbons
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2019-04-29 , DOI: 10.1021/jacs.9b02844
Samantha A Green ₁ , Tucker R Huffman ₁ , Ruairí O McCourt ₁ , Vincent van der Puyl ₁ , Ryan A Shenvi ₁

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Metal-hydride hydrogen atom transfer (MHAT) functionalizes alkenes with predictable branched (Markovnikov) selectivity. The breadth of these transformations has been confined to π-radical traps; no sp3 electrophiles have been reported. Here we describe a Mn/Ni dual catalytic system that hydroalkylates unactivated olefins with unactivated alkyl halides, yielding aliphatic quaternary carbons.

中文翻译：

烯烃加氢烷基化形成季碳

金属氢化物氢原子转移 (MHAT) 以可预测的支链 (Markovnikov) 选择性功能化烯烃。这些转变的广度仅限于 π 自由基陷阱。没有报道 sp3 亲电体。在这里，我们描述了一种 Mn/Ni 双催化体系，该体系用未活化的卤代烷对未活化的烯烃进行氢化烷基化，产生脂肪族季碳。

更新日期：2019-04-29

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