探索碳点和阿霉素盐酸盐组装体发光响应的简单智能方法：白光产生和依赖pH的可逆光开关<a href="#fn1" title="提供电子补充信息（ESI）：详细的仪器，支持表和支持图。参见DOI：10.1039 / c9tc01629e">†</a>,Journal of Materials Chemistry C

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探索碳点和阿霉素盐酸盐组装体发光响应的简单智能方法：白光产生和依赖pH的可逆光开关 †
Journal of Materials Chemistry C ( IF 5.7 ) Pub Date : 2019-04-26 00:00:00 , DOI: 10.1039/c9tc01629e
Arghajit Pyne _{1,

2,

3,

4} , Souvik Layek _{1,

2,

3,

4} , Avijit Patra _{1,

2,

3,

4} , Nilmoni Sarkar _{1,

2,

3,

4}

Affiliation

碳点（CD）在药物输送系统，生物成像探针以及具有可调发射特性的不同光电设备中的卓越和广泛应用，影响了我们在其药物输送和发光响应之间架起一座桥梁。在这种情况下，我们使用微波方法从柠檬酸（CA）和尿素中合成并纯化了CD，并使用几种光谱和显微镜技术对其进行了全面表征。研究了合成CD系统有趣的pH依赖性和pH可逆性。当溶液的pH值从12变为2时，CD中加载的抗癌药盐酸阿霉素（Dox）产生白光（WL），并且该WL系统在pH 2和12之间显示可逆的“ ON-OFF”光开关。进一步研究了这种WL生成的可能机理是各个组分之间的荧光共振能量转移（FRET），因此，对于pH依赖性的可逆光开关，该机理被确立为CD和Dox的pH响应。WL系统还在琼脂糖凝胶基质中保留了其光学性质。因此，本研究可以为建模具有有趣的发光特性的基于CD的智能药物输送系统开辟新的视野，因此可以应用于构建未来的药物输送以及发光装置。WL系统还在琼脂糖凝胶基质中保留了其光学性质。因此，本研究可以为建模具有有趣的发光特性的基于CD的智能药物输送系统开辟新的视野，因此可以应用于构建未来的药物输送以及发光装置。WL系统还在琼脂糖凝胶基质中保留了其光学性质。因此，本研究可以为建模具有有趣的发光特性的基于CD的智能药物输送系统开辟新的视野，因此可以应用于构建未来的药物输送以及发光装置。

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An easy and smart way to explore the light-emitting responses of carbon dot and doxorubicin hydrochloride assembly: white light generation and pH-dependent reversible photoswitching†

The excellent and extensive application of carbon dots (CDs) as drug delivery systems, bioimaging probes as well as in different optoelectronic devices with tunable emission properties influenced us to make a bridge between their drug delivery and light-emitting responses. In this scenario, we synthesized and purified CD from citric acid (CA) and urea using microwave method and thoroughly characterized them using several spectroscopic and microscopic techniques. The interesting pH dependence and pH reversibility of the synthesized CD system was studied. The loading of the anticancer drug doxorubicin hydrochloride (Dox) in CD generated white light (WL) when the pH of the solution changed from pH 12 to 2 and this WL system showed reversible “ON–OFF” photoswitching between pH 2 and 12. The probable mechanism of this WL generation was further explored to be fluorescence resonance energy transfer (FRET) between the respective components and consequently, for pH-dependent reversible photoswitching, the mechanism was established to be the pH responses of both CD and Dox. The WL system also retained its optical properties in the agarose gel matrix. Therefore, this study may open a new horizon in modelling a smart CD-based drug delivery system with interesting light-emitting properties, and thus can be applicable in constructing future drug delivery as well as light-emitting devices.

更新日期：2019-04-26

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