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Near-Infrared-II Molecular Dyes for Cancer Imaging and Surgery.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-04-26 , DOI: 10.1002/adma.201900321 Shoujun Zhu 1 , Rui Tian 1 , Alexander L Antaris 2 , Xiaoyuan Chen 1 , Hongjie Dai 2
Advanced Materials ( IF 27.4 ) Pub Date : 2019-04-26 , DOI: 10.1002/adma.201900321 Shoujun Zhu 1 , Rui Tian 1 , Alexander L Antaris 2 , Xiaoyuan Chen 1 , Hongjie Dai 2
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Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target a variety of biological tissues and processes. This review focuses on summarizing organic dyes emitting at a biological transparency window termed the near‐infrared‐II (NIR‐II) window, where minimal light interaction with the surrounding tissues allows photons to travel nearly unperturbed throughout the body. NIR‐II fluorescence imaging overcomes the penetration/contrast bottleneck of imaging in the visible region, making it a remarkable modality for early diagnosis of cancer and highly sensitive tumor surgery. Due to their convenient bioconjugation with peptides/antibodies, NIR‐II molecular dyes are desirable candidates for targeted cancer imaging, significantly overcoming the autofluorescence/scattering issues for deep tissue molecular imaging. To promote the clinical translation of NIR‐II bioimaging, advancements in the high‐performance small molecule–derived probes are critically important. Here, molecules with clinical potential for NIR‐II imaging are discussed, summarizing the synthesis and chemical structures of NIR‐II dyes, chemical and optical properties of NIR‐II dyes, bioconjugation and biological behavior of NIR‐II dyes, whole body imaging with NIR‐II dyes for cancer detection and surgery, as well as NIR‐II fluorescence microscopy imaging. A key perspective on the direction of NIR‐II molecular dyes for cancer imaging and surgery is also discussed.
中文翻译：
用于癌症成像和手术的近红外-II 分子染料。
荧光生物成像为研究人员和外科医生提供了分子靶向各种生物组织和过程的重要工具。本综述重点总结了在称为近红外 II (NIR-II) 窗口的生物透明窗口发射的有机染料，其中与周围组织的最小光相互作用允许光子在整个身体中几乎不受干扰地传播。 NIR-II 荧光成像克服了可见光区域成像的穿透/对比度瓶颈，使其成为癌症早期诊断和高灵敏度肿瘤手术的卓越方式。由于能够方便地与肽/抗体进行生物共轭，NIR-II 分子染料是靶向癌症成像的理想候选者，显着克服了深部组织分子成像的自发荧光/散射问题。为了促进 NIR-II 生物成像的临床转化，高性能小分子衍生探针的进步至关重要。在这里，讨论了具有 NIR-II 成像临床潜力的分子，总结了 NIR-II 染料的合成和化学结构、NIR-II 染料的化学和光学性质、NIR-II 染料的生物共轭和生物学行为、全身成像用于癌症检测和手术的 NIR-II 染料，以及 NIR-II 荧光显微镜成像。还讨论了 NIR-II 分子染料用于癌症成像和手术的方向的关键观点。
更新日期：2019-04-26
中文翻译：
用于癌症成像和手术的近红外-II 分子染料。
荧光生物成像为研究人员和外科医生提供了分子靶向各种生物组织和过程的重要工具。本综述重点总结了在称为近红外 II (NIR-II) 窗口的生物透明窗口发射的有机染料，其中与周围组织的最小光相互作用允许光子在整个身体中几乎不受干扰地传播。 NIR-II 荧光成像克服了可见光区域成像的穿透/对比度瓶颈，使其成为癌症早期诊断和高灵敏度肿瘤手术的卓越方式。由于能够方便地与肽/抗体进行生物共轭，NIR-II 分子染料是靶向癌症成像的理想候选者，显着克服了深部组织分子成像的自发荧光/散射问题。为了促进 NIR-II 生物成像的临床转化，高性能小分子衍生探针的进步至关重要。在这里，讨论了具有 NIR-II 成像临床潜力的分子，总结了 NIR-II 染料的合成和化学结构、NIR-II 染料的化学和光学性质、NIR-II 染料的生物共轭和生物学行为、全身成像用于癌症检测和手术的 NIR-II 染料，以及 NIR-II 荧光显微镜成像。还讨论了 NIR-II 分子染料用于癌症成像和手术的方向的关键观点。
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