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A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO
Green Chemistry ( IF 9.3 ) Pub Date : 2019-04-24 , DOI: 10.1039/c9gc00886a
Wei-Guo Shen 1, 2, 3, 4, 5 , Qing-Yan Wu 1, 2, 3, 4, 5 , Xing-Yu Gong 1, 2, 3, 4, 5 , Gui-Zhen Ao 1, 2, 3, 4, 5 , Feng Liu 1, 2, 3, 4, 5
Affiliation  

A practical hydroxytrifluoromethylation of alkenes using the Langlois reagent as the trifluoromethyl source and DMSO as the oxidant is described. This reaction is mild and operationally simple, without exclusion of either moisture or oxygen, allowing access to a wide range of β-trifluoromethyl alcohols in useful yields. This transformation is environmentally friendly and can be easily scaled up to gram level.

中文翻译:

用Langlois试剂和DMSO进行烯烃的羟基三氟甲基化的简便方法

描述了使用Langlois试剂作为三氟甲基源和DMSO作为氧化剂的烯烃的实际羟基三氟甲基化。该反应温和且操作简单,不排除湿气或氧气,从而允许以有用的产率获得各种β-三氟甲基醇。这种转变是环保的,可以轻松按比例放大至克级。
更新日期:2019-06-04
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