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Responsive Porous Microcarriers With Controllable Oxygen Delivery for Wound Healing.
Small ( IF 13.0 ) Pub Date : 2019-04-17 , DOI: 10.1002/smll.201901254
Yuxiao Liu 1 , Xin Zhao 2 , Cheng Zhao 2 , Hui Zhang 1 , Yuanjin Zhao 1
Affiliation  

Microcarriers with oxygen‐delivering capacity have attracted increasing interest in the field of tissue regeneration. Here, a kind of molybdenum disulfide quantum dots (MoS2 QDs) integrated responsive porous microcarriers with controllable oxygen‐delivering ability for wound healing is presented. The specific gelatin methacryloyl (GelMa) porous microcarriers are derived from inverse opal microparticles which can be decorated with the oxygen‐carrying protein hemoglobin. Because of their characteristic porous structure, interconnected nanochannels, and excellent biocompatibility, the resultant microcarriers could carry oxygen extensively and provide support for tissue repair physically and biologically. Besides, since the typical photothermal effect of 2D materials and their derived 2D QDs, the inverse opal particles integrated with MoS2 QDs are imparted with photo‐responsive capacity, which makes them able to release oxygen photo‐controllably. It is demonstrated that the designed microcarriers can promote the repair of abdominal wall defects effectively with their multifunctional features. These remarkable properties point to the potential value of the microcarriers in wound healing and tissue engineering.

中文翻译:

响应性多孔微载体,具有可控制的氧气输送能力,可用于伤口愈合。

具有氧气输送能力的微载体在组织再生领域引起了越来越多的兴趣。在这里,一种二硫化钼量子点(MoS 2QDs)集成了响应性多孔微载体,具有可控制的氧气输送能力,可用于伤口愈合。特定的明胶甲基丙烯酰基(GelMa)多孔微载体源自蛋白石微颗粒,可以用载氧蛋白血红蛋白修饰。由于其特有的多孔结构,相互连接的纳米通道以及出色的生物相容性,所得的微载体可以广泛地携带氧气并为组织的物理和生物学修复提供支持。此外,由于2D材料及其衍生的2D QD具有典型的光热效应,因此反蛋白石颗粒与MoS 2集成在一起QD具有光响应能力,这使它们能够以光控方式释放氧气。结果表明,所设计的微载体具有多种功能,可以有效促进腹壁缺损的修复。这些非凡的特性表明了微载体在伤口愈合和组织工程中的潜在价值。
更新日期:2019-04-17
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