To dates, the facile synthesis of inorganic-coated organic polymer composite has received greater attention in the order of research fields including advanced materials and electrochemical analysis owing to the complementary or synergistic effects. In this context, Pr₂O₃ and Pr₂O₃ coated polystyrene (Pr₂O₃/PS) inorganic-organic colloidal composite were prepared via ultrasound-induced radicals initiated precipitation and dispersion polymerization methods. The synthesized Pr₂O₃/PS composite was systematically studied by FE-SEM, TEM, EDX, FT-IR, XRD, and XPS analysis. This composite modified glassy carbon electrode (Pr₂O₃/PS GCE) was utilized to construct a novel electrochemical sensor for the detection assay of chemotherapy agent methotrexate (MTA). Under optimal condition, the designed sensor showed outstanding performance for MTA trace level detection over the linear concentration range of 0.01-236 µM with a detection limit of 0.8 nM for MTA. Furthermore, the prepared sensor accomplished excellent stability and relevant reproducibility, in addition to reliable practical assay in real human blood serum and urine samples. Besides, the possible MTA sensing mechanism of Pr₂O₃/PS GCE have been deliberated in detail. Our finding suggested that the developed Pr₂O₃/PS composite might be a favorable material for the fabrication of the high-performance electrochemical sensor.

迄今为止，由于互补或协同作用，无机涂层有机聚合物复合材料的简便合成在包括高级材料和电化学分析在内的研究领域中受到了越来越多的关注。在这种情况下，通过超声诱导的自由基引发的沉淀和分散聚合方法制备了Pr ₂ O ₃和Pr ₂ O ₃包覆的聚苯乙烯（Pr ₂ O ₃ / PS）无机-有机胶体复合物。通过FE-SEM，TEM，EDX，FT-IR，XRD和XPS分析系统地研究了合成的Pr ₂ O ₃ / PS复合材料。该复合改性玻碳电极（Pr ₂O ₃ / PS GCE）被用来构建一种新型的电化学传感器，用于化学试剂甲氨蝶呤（MTA）的检测分析。在最佳条件下，设计的传感器在0.01-236 µM的线性浓度范围内对MTA痕量水平检测表现出卓越的性能，对MTA的检测极限为0.8 nM。此外，除了在真实的人血清和尿液样品中进行可靠的实用测定之外，所制备的传感器还具有出色的稳定性和相关的可重复性。此外，还详细讨论了Pr ₂ O ₃ / PS GCE可能的MTA感应机制。我们的发现表明，已开发的Pr ₂ O ₃/ PS复合材料可能是制造高性能电化学传感器的理想材料。