Antibiotics are commonly used to fight against bacterial infections, but bacteria have already been resistant to almost all antibiotics due to abuse of antibiotics. 1,2,4-Triazole derived compounds possess chemotherapeutic effects including potential antibacterial activities against drug-sensitive as well as drug-resistant pathogens. Hybridization displays a high potential to develop novel drugs with the capacity to overcome drug resistance, reduce toxicity and improve pharmacokinetic profiles. More effective antibacterial candidates might be obtained by the hybridization of 1,2,4-triazole with other antibacterial pharmacophores. This review summarizes the recent advances of 1,2,4-triazole derivatives as potential antibacterial compounds, and the structure-activity relationship is also discussed.

抗生素通常用于抵抗细菌感染，但是由于滥用抗生素，细菌已经对几乎所有的抗生素产生抗药性。1,2,4-三唑衍生的化合物具有化学治疗作用，包括对药物敏感性和耐药性病原体的潜在抗菌活性。杂交显示出开发具有克服耐药性，降低毒性和改善药代动力学特性的新药的巨大潜力。通过将1,2,4-三唑与其他抗菌药效团杂交可获得更有效的抗菌候选物。这篇综述总结了1,2,4-三唑衍生物作为潜在的抗菌化合物的最新进展，并讨论了其构效关系。