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α-Keto Acids: Acylating Agents in Organic Synthesis.
Chemical Reviews ( IF 51.4 ) Pub Date : 2019-04-16 , DOI: 10.1021/acs.chemrev.8b00782 Filipe Penteado 1 , Eric F Lopes 1 , Diego Alves 1 , Gelson Perin 1 , Raquel G Jacob 1 , Eder J Lenardão 1
Chemical Reviews ( IF 51.4 ) Pub Date : 2019-04-16 , DOI: 10.1021/acs.chemrev.8b00782 Filipe Penteado 1 , Eric F Lopes 1 , Diego Alves 1 , Gelson Perin 1 , Raquel G Jacob 1 , Eder J Lenardão 1
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A significant number of important acyl-transfer reactions, such as direct acylation, ortho acylation, heteroatom acylation, and a diversity of cyclization reactions using the title compound as a key starting material, have been described in recent years. Just like a sleeping beauty, α-oxocarboxylic acids were awakened from a 17-year sleep to become important reagents in classical and new acylation reactions. The greener characteristic of the coproduct formed in reactions using α-keto acid (only CO2), together with its versatility as a building block in catalytic organic synthesis, accredit it as a candidate to green acylating agent, an alternative to acyl chloride, and other acyl-transfer reagents. This review presents the impressive breakthroughs achieved mainly in the past decade in the development of new catalytic reactions for the formation of C-C, C-N, and C-S bonds using α-keto acids.
中文翻译：
α-酮酸：有机合成中的酰化剂。
近年来，已经描述了许多重要的酰基转移反应，例如直接酰化，邻位酰化，杂原子酰化，以及使用标题化合物作为关键原料的各种环化反应。就像睡美人一样，α-氧代羧酸从17年的睡眠中醒来，成为经典和新酰化反应中的重要试剂。使用α-酮酸（仅CO2）在反应中形成的副产物的绿色特征，以及其多功能性作为催化有机合成的基础，使其成为绿色酰化剂，酰氯的替代品和其他产品的候选者酰基转移试剂。
更新日期：2019-04-16
中文翻译：
α-酮酸：有机合成中的酰化剂。
近年来，已经描述了许多重要的酰基转移反应，例如直接酰化，邻位酰化，杂原子酰化，以及使用标题化合物作为关键原料的各种环化反应。就像睡美人一样，α-氧代羧酸从17年的睡眠中醒来，成为经典和新酰化反应中的重要试剂。使用α-酮酸（仅CO2）在反应中形成的副产物的绿色特征，以及其多功能性作为催化有机合成的基础，使其成为绿色酰化剂，酰氯的替代品和其他产品的候选者酰基转移试剂。
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