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T cells and the skin: from protective immunity to inflammatory skin disorders.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-08-01 , DOI: 10.1038/s41577-019-0162-3 Allen W Ho 1 , Thomas S Kupper 1
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-08-01 , DOI: 10.1038/s41577-019-0162-3 Allen W Ho 1 , Thomas S Kupper 1
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Skin is our primary interface with the environment, and T cells are crucial for orchestrating host immune responses against pathogenic microorganisms at this site. Effective skin immune responses require the generation of antigen-specific effector T cells, which home to cutaneous sites of injury or infection. Long-lasting immunity against future immune challenges is mediated by memory T cells. Among the memory T cells found in skin are both recirculating cells that transit between skin and blood and tissue-resident memory T (TRM) cells, which remain in skin for long periods of time and mediate durable protective immunity. These TRM cells also appear to drive many inflammatory diseases of skin. Here, we consider how a better understanding of cutaneous T cell responses can aid in the development of effective new therapies for immune-mediated cutaneous diseases.
中文翻译：
T 细胞和皮肤：从保护性免疫到炎症性皮肤病。
皮肤是我们与环境的主要界面，T 细胞对于协调宿主对该部位病原微生物的免疫反应至关重要。有效的皮肤免疫反应需要产生抗原特异性效应 T 细胞，这些细胞位于皮肤损伤或感染部位。针对未来免疫挑战的持久免疫是由记忆 T 细胞介导的。在皮肤中发现的记忆 T 细胞中，既有在皮肤和血液之间传输的循环细胞，也有组织驻留记忆 T (TRM) 细胞，它们可以长时间留在皮肤中并介导持久的保护性免疫。这些 TRM 细胞似乎也引发了许多皮肤炎症性疾病。这里，
更新日期：2019-05-16
中文翻译：
T 细胞和皮肤：从保护性免疫到炎症性皮肤病。
皮肤是我们与环境的主要界面，T 细胞对于协调宿主对该部位病原微生物的免疫反应至关重要。有效的皮肤免疫反应需要产生抗原特异性效应 T 细胞，这些细胞位于皮肤损伤或感染部位。针对未来免疫挑战的持久免疫是由记忆 T 细胞介导的。在皮肤中发现的记忆 T 细胞中，既有在皮肤和血液之间传输的循环细胞，也有组织驻留记忆 T (TRM) 细胞，它们可以长时间留在皮肤中并介导持久的保护性免疫。这些 TRM 细胞似乎也引发了许多皮肤炎症性疾病。这里，
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