当前位置:
X-MOL 学术
›
Adv. Healthcare Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Magnetic Hydrogel with Optimally Adaptive Functions for Breast Cancer Recurrence Prevention.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-04-15 , DOI: 10.1002/adhm.201900203
Fei Gao 1 , Wensheng Xie 2 , Yuqing Miao 1 , Dan Wang 2 , Zhenhu Guo 2 , Anujit Ghosal 1 , Yongsan Li 3 , Yen Wei 3 , Si-Shen Feng 4 , Lingyun Zhao 2 , Hai Ming Fan 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-04-15 , DOI: 10.1002/adhm.201900203
Fei Gao 1 , Wensheng Xie 2 , Yuqing Miao 1 , Dan Wang 2 , Zhenhu Guo 2 , Anujit Ghosal 1 , Yongsan Li 3 , Yen Wei 3 , Si-Shen Feng 4 , Lingyun Zhao 2 , Hai Ming Fan 1
Affiliation
Engineering biocompatible hydrogels using functional nanoparticles has attracted considerable attention because of their uniquely appealing cooperative effects that can enable multimodality imaging and treatment with improved efficacy against serious diseases. However, the effects of high‐content nanoparticle dopants on the rheological properties of hydrogels frequently lead to an unsatisfactory therapeutic result, which is particularly notable in the design of magnetic hydrogel formulations for cancer therapy. Herein is reported a novel magnetic hydrogel functionalized by ferromagnetic vortex‐domain iron oxide (FVIOs) with optimally adaptive functions for prevention of breast cancer recurrence. The FVIOs can perfectly incorporate into the dynamic hydrogel networks with an extremely low concentration (0.6 mg mL−1), 17 times lower than that of conventional superparamagnetic iron oxide nanoparticles with sufficient heating capacity. Such magnetic hydrogels exhibit high inductive heating and remarkable rheological properties simultaneously. Moreover, the self‐healing, self‐conformal ability, controlled release of loaded doxorubicin, biodegradation, and pH‐responsiveness of the magnetic hydrogel project their efficient sustainable therapeutic ability. In vivo postoperative treatment has further demonstrated the high efficacy of FVIO‐based magnetic hydrogels, as evidenced by the significant suppression of the local tumor recurrences compared to chemotherapy or hyperthermia alone. This unique magnetic hydrogel formulation with optimally adaptive functions shows strong potential in preventing relapses of various cancers.
中文翻译:
具有最佳适应功能的磁性水凝胶可预防乳腺癌复发。
使用功能性纳米粒子对生物相容性水凝胶进行工程设计已经引起了广泛的关注,因为它们具有独特的吸引力的协同效应,可以实现多模态成像和治疗,从而改善对严重疾病的疗效。但是,高含量的纳米粒子掺杂剂对水凝胶流变特性的影响通常会导致治疗效果不理想,这在用于癌症治疗的磁性水凝胶制剂的设计中尤为明显。本文报道了一种由铁磁涡旋域氧化铁(FVIOs)功能化的新型磁性水凝胶,具有最佳的适应性功能,可预防乳腺癌的复发。FVIO可以以极低的浓度(0.6 mg mL -1)完美地结合到动态水凝胶网络中),是具有足够加热能力的常规超顺磁性氧化铁纳米颗粒的17倍。此类磁性水凝胶同时具有高感应加热和出色的流变性。此外,磁性水凝胶的自我修复,自我保形能力,负载的阿霉素的控释,生物降解和pH响应性都表明了其有效的可持续治疗能力。体内术后治疗进一步证明了基于FVIO的磁性水凝胶的高效性,与单独化疗或热疗相比,可显着抑制局部肿瘤复发证明了这一点。这种具有最佳适应功能的独特磁性水凝胶制剂在预防各种癌症复发方面显示出强大的潜力。
更新日期:2019-04-15
中文翻译:
具有最佳适应功能的磁性水凝胶可预防乳腺癌复发。
使用功能性纳米粒子对生物相容性水凝胶进行工程设计已经引起了广泛的关注,因为它们具有独特的吸引力的协同效应,可以实现多模态成像和治疗,从而改善对严重疾病的疗效。但是,高含量的纳米粒子掺杂剂对水凝胶流变特性的影响通常会导致治疗效果不理想,这在用于癌症治疗的磁性水凝胶制剂的设计中尤为明显。本文报道了一种由铁磁涡旋域氧化铁(FVIOs)功能化的新型磁性水凝胶,具有最佳的适应性功能,可预防乳腺癌的复发。FVIO可以以极低的浓度(0.6 mg mL -1)完美地结合到动态水凝胶网络中),是具有足够加热能力的常规超顺磁性氧化铁纳米颗粒的17倍。此类磁性水凝胶同时具有高感应加热和出色的流变性。此外,磁性水凝胶的自我修复,自我保形能力,负载的阿霉素的控释,生物降解和pH响应性都表明了其有效的可持续治疗能力。体内术后治疗进一步证明了基于FVIO的磁性水凝胶的高效性,与单独化疗或热疗相比,可显着抑制局部肿瘤复发证明了这一点。这种具有最佳适应功能的独特磁性水凝胶制剂在预防各种癌症复发方面显示出强大的潜力。